Establishment of an intraoperative staging system (iStage) by improving UICC TNM classification system for papillary thyroid carcinoma.

World Journal of Surgery
Yasuhiro ItoAkira Miyauchi

Abstract

Papillary thyroid carcinoma generally has an indolent nature, but cases demonstrating certain features are progressive. UICC TNM classification is the most widely adopted system to evaluate the biological behavior of this carcinoma, but it is doubtful whether this system that evaluates only the preoperative findings can appropriately reflect patient prognosis. In this study, we established a new staging system (iStage) based on not only preoperative but also intraoperative findings. We investigated the prognoses of 5,911 patients with papillary carcinoma without distant metastasis at diagnosis who underwent initial surgery between January 1987 and January 2005 and compared the utility of iStage with that of conventional classification systems, such as UICC Stage, MACIS score (>7 and ≤7), AMES, and CIH classification. Disease-free survival (DFS) and cause-specific survival (CSS) of patients with stage IVA were better than those of high-risk patients on other systems, and CSS of stage III patients did not differ from stage IVA patients. We established iStage by improving the original UICC stage. We set cutoff age to 55 years, instead of 45. Patients showing significant, not minimal, extrathyroid extension on intraoperative findin...Continue Reading

References

Feb 1, 1995·Thyroid : Official Journal of the American Thyroid Association·A AntonelliL Baschieri
Aug 16, 2008·Endocrine Journal·Yasuhiro Ito, Akira Miyauchi
Dec 17, 2008·Surgery·Yasuhiro ItoAkira Miyauchi

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Citations

Nov 9, 2010·Endocrine Pathology·Elaine Cristina MorariLaura Sterian Ward
Oct 7, 2011·Journal of Thyroid Research·Yasuhiro Ito, Akira Miyauchi
Jun 17, 2011·World Journal of Gastroenterology : WJG·Qiao-Mei DongXiao-Hang Zhao
Sep 21, 2013·World Journal of Surgery·Yasuhiro ItoAkira Miyauchi
Sep 5, 2013·Thyroid : Official Journal of the American Thyroid Association·Yasuhiro ItoAkihiro Miya
Sep 29, 2011·World Journal of Surgery·Yasuhiro ItoAkira Miyauchi
Oct 2, 2013·World Journal of Surgery·Kenichi MatsuzuKoichi Ito
Aug 8, 2014·Endocrine Journal·Yasuhiro ItoAkihiro Miya
Mar 8, 2016·Future Oncology·Laura Y Wang, Ian Ganly
Feb 20, 2016·Thyroid : Official Journal of the American Thyroid Association·Mark L UrkenBruce M Wenig
Jan 13, 2015·Pathology Oncology Research : POR·Rehab Allah Ahmed, Engy M Aboelnaga
Nov 21, 2012·Journal of the Korean Surgical Society·Jin Seong ChoHee Kyung Kim
Feb 9, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Andréa Farias de Melo-LeiteJorge Elias
Mar 1, 2017·Expert Review of Endocrinology & Metabolism·Fabio MainoFurio Pacini
May 6, 2020·World Journal of Clinical Cases·Xin WuXiao-Dong He
Jul 31, 2018·Expert Review of Endocrinology & Metabolism·Agathoklis KonstantinidisSanziana A Roman

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