Establishment of cell cultures persistently infected with spotted fever group rickettsiae

Canadian Journal of Microbiology
W J ToddA J Mavros

Abstract

A cell line was established from the tunica vaginalis of meadow voles, Microtus pennsylvanicus, which could be persistently infected with the spotted fever group rickettsiae, Rickettsia rickettsii, R. rhipicephali, and R. slovaca. As determined by light and electron microscopy, all cells in the cultures became infected and remained so even after 20 serial passages over a period of months. The rickettsiae-infected vole cell line is an excellent experimental model to study the noncytolytic host-cell interactions required for persistence of spotted fever group rickettsiae in nature.

Citations

Aug 4, 2006·Applied and Environmental Microbiology·Walairat PornwiroonKevin R Macaluso
Jun 23, 2009·Annals of the New York Academy of Sciences·Christopher D Paddock
Jan 1, 1988·Microbiology and Immunology·T Uchiyama, T Uchida
Oct 6, 2016·PLoS Neglected Tropical Diseases·Kerry A PadgettVicki Kramer
Jan 1, 1990·Annals of the New York Academy of Sciences·J Turco, H H Winkler
May 1, 1991·European Journal of Epidemiology·O G Baca
Apr 11, 2009·Veterinary Research·Cristina SocolovschiPhilippe Parola

Related Concepts

Metazoa
Ondatra
Microscopy
Electron Microscopy
Rickettsia
Rickettsia rickettsii

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