Establishment of haematological and immunological reference values for healthy Tanzanian children in Kilimanjaro Region.

Tropical Medicine & International Health : TM & IH
Ann M BuchananColeen K Cunningham

Abstract

To determine the normal haematological and immunological reference intervals for healthy Tanzanian children. We analysed data from 655 HIV-seronegative, healthy children from 1 month to 18 years of age from the Kilimanjaro Region of Tanzania for this cross-sectional study. Median and 95% reference ranges were determined for haematological and immunological parameters and analysed by age cohorts, and by gender for adolescents. Median haemoglobin (Hb) and haematocrit (Hct) for all age groups were higher than established East African reference intervals. Compared to U.S. intervals, reference ranges encompassed lower values for Hb, Hct, mean corpuscular volume, and platelets. Applying the U.S. National Institute of Health Division of AIDS (DAIDS) adverse event grading criteria commonly used in clinical trials to the reference range participants, 128 (21%) of 619 children would be classified as having an adverse event related to Hb level. CD4-positive T-lymphocyte absolute counts declined significantly with increasing age (P < 0.0001). For those aged under five years, CD4-positive T-lymphocyte percentages are lower than established developed country medians. Country-specific reference ranges are needed for defining normal laboratory...Continue Reading

References

Jul 1, 1987·Journal of Adolescent Health Care : Official Publication of the Society for Adolescent Medicine·S CharacheH Wong
Aug 1, 1973·British Journal of Preventive & Social Medicine·C Murray
Mar 1, 1995·Clinical and Diagnostic Laboratory Immunology·S B TugumeE Katongole-Mbidde
Jul 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·A Dunn, A Macfarlane
Dec 23, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·M BoothP Kilima
May 4, 1999·Clinical and Diagnostic Laboratory Immunology·A TsegayeT F Rinke de Wit
Jun 29, 1999·The Journal of Laboratory and Clinical Medicine·T B HaddyO Castro
May 3, 2001·The Pediatric Infectious Disease Journal·J EmbreeF Plummer
Sep 13, 2002·The American Journal of Tropical Medicine and Hygiene·Patrick GérardinPatrick Imbert
May 10, 2003·Clinical and Diagnostic Laboratory Immunology·Didier MenardAntoine Talarmin
Nov 12, 2003·The Journal of Allergy and Clinical Immunology·William T ShearerUNKNOWN Pediatric AIDS Clinical Trials Group
Jan 13, 2004·Clinical and Diagnostic Laboratory Immunology·Eric S LugadaRobert Downing
Jul 7, 2005·The Pediatric Infectious Disease Journal·Madeleine BundersUNKNOWN European Collaborative Study
Oct 24, 2006·Tropical Medicine & International Health : TM & IH·Llorenç QuintóPedro L Alonso
Jan 25, 2007·Annals of Tropical Medicine and Parasitology·J MakaniK Marsh
Jun 29, 2007·The Journal of Infectious Diseases·Anders EnevoldChris J Drakeley
Aug 19, 2007·Indian Journal of Pediatrics·Renu SaxenaVed P Choudhry
Mar 12, 2008·Tropical Medicine & International Health : TM & IH·Elmar SaathoffMichael Hoelscher
Jul 3, 2008·Annual Review of Genomics and Human Genetics·Michael C Campbell, Sarah A Tishkoff
Jul 18, 2008·International Journal of Laboratory Hematology·I M O AdetifaR A Adegbola
Mar 28, 2009·PLoS Medicine·Simon I HayRobert W Snow
Jun 1, 1980·Journal of Youth and Adolescence·N M Morris, J R Udry

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Citations

Jun 30, 2012·Transactions of the Royal Society of Tropical Medicine and Hygiene·Sarah M LofgrenJohn A Crump
Aug 4, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Malavika PrabhuJohn A Crump
Nov 21, 2012·Paediatrics and International Child Health·Newton I KumwendaTaha E Taha
Dec 3, 2013·Malaria Journal·Maria A Santana-MoralesEnrique Martinez-Carretero
Aug 5, 2011·The American Journal of Tropical Medicine and Hygiene·Holly M BiggsJohn A Crump
Jan 11, 2012·The American Journal of Tropical Medicine and Hygiene·Julian T HertzJohn A Crump
Oct 24, 2012·The American Journal of Tropical Medicine and Hygiene·Andrew J BouleyJohn A Crump
May 9, 2014·International Journal of Environmental Research and Public Health·Nirianne M Q PalacpacToshihiro Horii
Jul 15, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Liting JiaJunfang Li
Jan 8, 2014·Tropical Medicine & International Health : TM & IH·Aderonke A OdutolaMartin O C Ota
Aug 1, 2015·Tropical Medicine & International Health : TM & IH·Ann M BuchananJohn A Crump
Jul 2, 2019·Annals of the New York Academy of Sciences·Max GassmannMartina U Muckenthaler
Feb 12, 2020·Environmental Science and Pollution Research International·Alejandra Manjarres-Suarez, Jesus Olivero-Verbel
Aug 18, 2020·BioMed Research International·Abdoul Habib BéavoguiAbdoulaye Djimdé
Aug 15, 2020·Frontiers in Pediatrics·Helen PayneNigel Klein
Apr 3, 2021·BMC Health Services Research·Benoît Mukinayi MbiyaBéatrice Gulbis

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