Establishment of Locally Adapted Mutations Under Divergent Selection

Genetics
Matteo Tomasini, Stephan Peischl

Abstract

We study the establishment probabilities of locally adapted mutations using a multi-type branching process framework. We find a surprisingly simple and intuitive analytical approximation for the establishment probabilities in a symmetric two-deme model under the assumption of weak (positive) selection. This is the first analytical closed-form approximation for arbitrary migration rate to appear in the literature. We find that the establishment probability lies between the weak and the strong migration limits if we condition the origin of the mutation to the deme where it is advantageous. This is not the case when we condition the mutation to first occur in a deme where it is disadvantageous. In this case we find that an intermediate migration rate maximizes the probability of establishment. We extend our results to the cases of multiple demes, two demes with asymmetric rates of gene flow, and asymmetric carrying capacities. The latter case allows us to illustrate how density regulation can affect establishment probabilities. Finally, we use our results to investigate the role of gene flow on the rate of local adaptation and identify cases in which intermediate amounts of gene flow facilitate the rate of local adaptation as comp...Continue Reading

References

Jan 1, 1976·Annual Review of Genetics·J Felsenstein
Dec 1, 1991·Genetical Research·H Tachida, M Iizuka
Apr 1, 1980·Journal of Mathematical Biology·T Nagylaki
Apr 1, 1994·Genetics·H A Orr, S P Otto
Jun 1, 1997·Genetics·S P Otto, M C Whitlock
Sep 3, 2004·Genetics·Claus O Wilke
Aug 25, 2005·Genetics·Michael C Whitlock, Richard Gomulkiewicz
May 17, 2006·Trends in Ecology & Evolution·Ole Seehausen
May 2, 2007·Theoretical Population Biology·Thomas Nagylaki, Yuan Lou
May 8, 2007·Genetics·Bastiaan StarHamish G Spencer
Jan 19, 2008·Genetics·Séverine VuilleumierNicolas Perrin
Jul 31, 2008·Journal of the Royal Society, Interface·Z Patwa, L M Wahl
Jun 6, 2009·Theoretical Population Biology·Thomas Nagylaki
Aug 12, 2009·Theoretical Population Biology·Reinhard Bürger
Sep 10, 2010·Theoretical Population Biology·S VuilleumierN Perrin
Dec 24, 2010·Journal of Evolutionary Biology·K D Behrman, M Kirkpatrick
Jul 7, 2011·Evolution; International Journal of Organic Evolution·Sam Yeaman, Sarah P Otto
May 1, 2012·Genetics·Stephan Peischl, Mark Kirkpatrick
Dec 5, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mark Kirkpatrick, Stephan Peischl
Dec 18, 2013·The American Naturalist·Hildegard UeckerJoachim Hermisson
Mar 13, 2014·Genetics·Simon Aeschbacher, Reinhard Bürger
Jul 20, 2014·Trends in Ecology & Evolution·Stephanie M CarlsonPeter A H Westley
Dec 3, 2014·Journal of Theoretical Biology·Xinzhu WeiDavid Waxman
Sep 1, 1975·Evolution; International Journal of Organic Evolution·Bruce Wallace
Nov 1, 1990·Evolution; International Journal of Organic Evolution·Michael Lynch, Wilfried Gabriel
Feb 1, 1995·Evolution; International Journal of Organic Evolution·Richard Gomulkiewicz, Robert D Holt

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Citations

Jun 17, 2020·Evolution; International Journal of Organic Evolution·Matteo Tomasini, Stephan Peischl
Feb 10, 2021·G3 : Genes - Genomes - Genetics·Takahiro Sakamoto, Hideki Innan
Mar 12, 2021·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Hideki Innan, Takahiro Sakamoto
Nov 19, 2021·Genetics·Bogi Trickovic, Sylvain Glémin

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