Establishment of methylation patterns in ES cells

Nature Structural & Molecular Biology
Ofra SabagHoward Cedar

Abstract

After erasure in the early animal embryo, a new bimodal DNA methylation pattern is regenerated at implantation. We have identified a demethylation pathway in mouse embryonic cells that uses hydroxymethylation (Tet1), deamination (Aid), glycosylation (Mbd4) and excision repair (Gadd45a) genes. Surprisingly, this demethylation system is not necessary for generating the overall bimodal methylation pattern but does appear to be involved in resetting methylation patterns during somatic-cell reprogramming.

References

May 16, 1991·Nature·D FrankH Cedar
Sep 29, 1994·Nature·M BrandeisH Cedar
Feb 17, 2000·Nature·W MayerT Haaf
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·V Rusmintratip, L C Sowers
Jul 12, 2002·The Journal of Biological Chemistry·Sharon Gidekel, Yehudit Bergman
Jan 31, 2006·Nature Genetics·Ilana KeshetItamar Simon
Feb 23, 2007·Molecular Biology of the Cell·Christel T FrebergPhilippe Collas
Jun 30, 2007·Oncogene·H J JungY R Seo
Jul 5, 2008·Nature·Alexander MeissnerEric S Lander
Apr 21, 2009·Nature Structural & Molecular Biology·Ravid StraussmanHoward Cedar
Apr 15, 2011·Nature·Kristine WilliamsKristian Helin
Dec 16, 2011·Nature·Michael B StadlerDirk Schübeler
Feb 14, 2012·Nature Chemical Biology·Liang ZhangChuan He
Mar 1, 2012·Nucleic Acids Research·Hideharu HashimotoXiaodong Cheng
Jul 10, 2012·Nature Chemical Biology·Christopher S NabelRahul M Kohli
Nov 21, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jamie A Hackett, M Azim Surani

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Citations

May 24, 2014·PloS One·Guy LudwigHoward Cedar
Dec 24, 2014·PloS One·Nobuyoshi ShimodaYutaka Kikuchi
Aug 9, 2016·Chemical Reviews·Alexander C Drohat, Christopher T Coey
Nov 20, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Matthias BochtlerGuo-Liang Xu
Jan 18, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Lars Schomacher, Christof Niehrs
Sep 25, 2017·Angewandte Chemie·Thomas CarellFabio Spada
Jun 10, 2018·Genes & Development·Andrea SchäferChristof Niehrs
Dec 20, 2014·Epigenetics & Chromatin·Richard B Meagher
Jun 7, 2019·Genes & Development·Katrin M SchüleChristof Niehrs
Aug 4, 2018·Analytical Cellular Pathology (Amsterdam)·Anubhav Chakraborty, Pragasam Viswanathan
Sep 28, 2018·Proceedings of the National Academy of Sciences of the United States of America·Razi GreenfieldHoward Cedar
May 11, 2016·Journal of Immunological Methods·Natalie M HohosRichard B Meagher
Jun 2, 2016·DNA Repair·David SchuermannPrimo Schär
Jun 16, 2021·JCI Insight·Jeffrey T EhmsenAhmet Höke

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