Establishment of reference intervals for soluble ST2 from a United States population

Clinica Chimica Acta; International Journal of Clinical Chemistry
Jun LuDavid G Grenache

Abstract

Soluble ST2 (sST2) is a protein in the interleukin-1 receptor family secreted by myocytes in response to mechanical strain. Elevated sST2 is strongly prognostic in patients with heart failure. sST2 was measured using the Presage ST2 ELISA. Evaluation included imprecision, linearity, recovery, analytical sensitivity, limit of quantification, stability, and sample type comparisons. Gender-specific reference intervals were established from 245 male and 245 female serum specimens. At sST2 concentrations of 11.6, 26.9, and 88.0 ng/mL, the within-day CV was 7.6, 2.4, and 3.8%, respectively and the total CV was 11.5, 14.0, and 6.3%, respectively. The assay was linear over a concentration range of 2.8-161.1 ng/mL (y=0.95x+2.25; R(2)=0.997; Sy.x=3.03). The limit of quantification was 3.3 ng/mL. sST2 was stable for 2 days at room temperature, 10days at 4 °C, and 30 days at -20 °C. Concentrations of sST2 were significantly higher in males compared to females (24.9 vs. 16.9 ng/mL; p<0.0001) but were not correlated by age in either gender (r=-0.07; p=0.14). Reference intervals for sST2 were determined to be 8.6-49.3 and 7.2-33.5 ng/mL for males and females, respectively. The Presage ST2 ELISA had acceptable performance characteristics for q...Continue Reading

References

May 12, 2007·The Journal of Clinical Investigation·Shoji SanadaRichard T Lee
Oct 2, 2008·Nature Reviews. Drug Discovery·Rahul Kakkar, Richard T Lee
Aug 25, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Benjamin DieplingerThomas Mueller
Dec 19, 2009·Circulation·UNKNOWN WRITING GROUP MEMBERSUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Apr 29, 2010·Current Heart Failure Reports·Ravi V Shah, James L Januzzi

❮ Previous
Next ❯

Citations

Jun 4, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Paola BrancaccioNicola Maffulli
Oct 21, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Benjamin DieplingerThomas Mueller
Dec 5, 2015·International Journal of Radiation Biology·Olya KatsarskaRayna Boteva
Aug 19, 2015·Clinical Biochemistry·Jeffrey W MeeusenAmy K Saenger
Aug 2, 2015·Clinical Biochemistry·Thomas MuellerBenjamin Dieplinger
Feb 24, 2015·The American Journal of Cardiology·Thomas Mueller, Allan S Jaffe
Oct 1, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Benjamin Dieplinger, Thomas Mueller
Apr 6, 2016·AIDS·Vikram MehrajUNKNOWN Montreal Primary HIV Infection, the Canadian Long-Term Non-Progressors Study Groups
Jul 11, 2018·Current Heart Failure Reports·Marin NishimuraAlan S Maisel
Oct 10, 2013·Circulation. Heart Failure·G Michael FelkerChristopher M O'Connor
Aug 3, 2016·Journal of the American Heart Association·Ravi H ParikhChristopher R deFilippi
Mar 14, 2014·Circulation. Heart Failure·Inder S AnandJay N Cohn
Jan 13, 2016·Circulation. Heart Failure·Michael R ZileUNKNOWN Prospective Comparison of ARNI With ARB on Management of Heart Failure With Preserved Ejection Fraction (PARAMOUNT) Investig
Sep 12, 2015·Annals of Laboratory Medicine·Mina HurUNKNOWN GREAT Network
May 28, 2019·Journal of Clinical Periodontology·Kitti TorrungruangArtit Udomsak
Oct 20, 2018·Medicine and Science in Sports and Exercise·Vincent L AengevaerenThijs M H Eijsvogels
May 12, 2017·Clinical and Translational Medicine·Shayan MoazeniKim-Lien Nguyen
Apr 8, 2020·Cardiac Failure Review·Veronika ZachFrank Edelmann
Aug 16, 2017·Annals of Clinical and Translational Neurology·Zoe WolcottW Taylor Kimberly
Feb 1, 2019·Heart·Laurie W GeenenJolien W Roos-Hesselink
Mar 29, 2020·European Journal of Heart Failure·Navin SuthaharRudolf A de Boer
Apr 27, 2017·Clinical Biochemistry·Xander M R van WijkElise D Riley
Jul 3, 2021·Biosensors·Rebeca M Torrente-RodríguezSusana Campuzano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.