Abstract
A pestivirus was transmitted by contact from a persistently infected (P.I.) bullock to pregnant sheep. This resulted in the birth of P.I. lambs, one of which in turn was able to transmit virus by contact to pregnant cattle. Two of these animals gave birth to P.I. calves, from one of which the virus was again transmitted by contact with pregnant sheep, leading to another generation of P.I. lambs. The expression of one or more epitopes on the E2 glycoprotein of the viruses isolated from this series of alternate cattle-sheep transmissions appeared to depend on the host species. Thus, several monoclonal antibodies which bound strongly to, and neutralised, viruses isolated from the bovine hosts, failed to bind or neutralise in the case of sheep isolates. The viral consensus sequences of the E2 gene as well as parts of the 5' untranslated region and of the Npro and capsid genes were compared between the different isolates. This revealed a high degree of genetic stability. However, a single codon change at amino acid position 9 of the E2 gene correlated with and was able to cause the loss of particular epitopes.
References
Jul 1, 1992·Comparative Immunology, Microbiology and Infectious Diseases·P F NettletonJ A Sinclair
Aug 29, 1992·The Veterinary Record·D J PatonS H Done
Oct 1, 1992·Virology·D J PatonA D Barrett
Aug 1, 1991·The Journal of General Virology·I Greiser-WilkeV Moennig
Jul 1, 1988·Virology·M S ColettA F Purchio
Jan 1, 1988·Archives of Virology·S EdwardsJ W Harkness
Aug 15, 1994·Biochemical and Biophysical Research Communications·H AdlerE Peterhans
Apr 1, 1995·Journal of Comparative Pathology·D J Paton
Oct 1, 1993·The Journal of General Virology·E DomingoM G Mateu
Mar 1, 1995·Veterinary Microbiology·D J PatonS Alenius
Aug 1, 1994·Journal of Comparative Pathology·D J Paton, S H Done
Feb 1, 1995·Journal of Virology·L J van DoornW Quint
Nov 1, 1994·The British Veterinary Journal·D J PatonG C Ramirez
Feb 14, 1995·Gene·C HertigE Peterhans
Jan 1, 1994·Archives of Virology·S VilcekD J Paton
Sep 1, 1994·Virology·C PellerinP Tijssen
Jan 1, 1993·The Journal of General Virology·W Xue, H C Minocha
Apr 1, 1997·The Journal of General Virology·S VilcekS Belák
Feb 22, 2000·Journal of Wildlife Diseases·S VilcekE C Anderson
Citations
Jul 13, 2006·Archives of Virology·A UttenthalL E Larsen
Mar 30, 2000·Vaccine·A J de SmitR J Moormann
Mar 17, 1999·Veterinary Microbiology·R L TothM A McCrae
Apr 1, 1994·New Zealand Veterinary Journal·M J PérezM Rice
Feb 19, 1998·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·T SandvikT Løken
Aug 24, 2010·Journal of Veterinary Internal Medicine·M MudryP Zanolari
May 17, 2013·Veterinary Research·Claudia BachofenErnst Peterhans
Apr 3, 2014·Veterinary Research·Claudia BachofenGeorge C Russell
Nov 22, 2000·The Veterinary Quarterly·A J de Smit
Jun 15, 2015·Veterinary Microbiology·John D NeillJulia F Ridpath
Jul 27, 2010·Veterinary Microbiology·Monica GiammarioliGian Mario De Mia
Jan 1, 2010·The Veterinary Journal·R Krametter-FroetscherW Baumgartner
Sep 29, 2009·Veterinary Microbiology·R StrongT Sandvik
Oct 11, 2005·Preventive Veterinary Medicine·Ase UttenthalL E Larsen
Dec 10, 2013·Veterinary Microbiology·U BraunE Peterhans
Jan 29, 2002·Microbial Pathogenesis·Somchai SwasdipanHelle Bielefeldt-Ohmann
Oct 5, 2011·Irish Veterinary Journal·Damien J BarrettH Michael Gunn
Nov 11, 2014·Annual Review of Animal Biosciences·Matthias Schweizer, Ernst Peterhans
Mar 8, 2018·The Veterinary Record·Caitlin Alexandra EvansPeter D Cockcroft
Mar 12, 2020·Microbial Genomics·George C RussellClaudia Bachofen
Jul 8, 2020·Journal of Veterinary Internal Medicine·Paul H WalzAmelia R Woolums
Jun 18, 2018·Virus Genes·Hongfei ShiLunguang Yao
Jun 27, 2020·Frontiers in Microbiology·Thibaud KucaPaul H Walz
Jun 22, 2018·Frontiers in Microbiology·Thibaud KucaPaul H Walz
Jun 22, 2000·The Journal of General Virology·M D FrayB Charleston
Oct 22, 2021·Frontiers in Veterinary Science·Andrea Franziska HuserMatthias Schweizer