PMID: 6159647Sep 1, 1980Paper

Establishment of the interferon-mediated antiviral state: role of fatty acid cyclooxygenase

Proceedings of the National Academy of Sciences of the United States of America
R PottathilD J Lang

Abstract

Inhibitors of fatty acid cyclooxygenase 8,11,14-icosatrienoate, hydrogen donor:oxygen oxidoreductase, EC 1.14.99.1) were found to suppress the establishment of the interferon-mediated antiviral state. The prevention, by these compounds, of the development of interferon protection correlated with the degree as well as the duration of cyclooxygenase inhibition. Anti-inflammatory substances lacking cyclooxygenase inhibitory activity did not interfere with the establishment of interferon protection. The addition of exogenous prostaglandins was not found to replace the need for a functional cyclooxygenase and, in some instances, could be shown to diminish the establishment of interferon protection. It is proposed that fatty acid cyclooxygenase is an essential component in the optimal induction of the interferon antiviral state.

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Citations

Jan 1, 1984·Pharmacology & Therapeutics·G C Sen
Aug 1, 1989·Biochimie·G LeblancM Bassilana
Jun 1, 1986·Brain Research Bulletin·J T CoyleJ D Gearhart
Jun 1, 1986·Brain Research Bulletin·R H ReevesJ W Littlefield
Jan 12, 1984·The New England Journal of Medicine·J S MoraT L Munsat
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S SayamaO Hayaishi
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R PottathilD J Lang
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R L FortiJ T Forbes
Jan 1, 1982·Journal of Interferon Research·M G ToveyJ P Kolb
Jan 1, 1982·Journal of Interferon Research·R B NasoC A Edbauer
Sep 1, 1990·Acta Neurologica Scandinavica·P O BehanD Horrobin
Feb 12, 1981·Biochemical and Biophysical Research Communications·K ChandraboseR Pottathil
Sep 21, 1982·Journal of Theoretical Biology·J A Scott
Aug 31, 1982·Biochemical and Biophysical Research Communications·M G SantoroA Benedetto
Oct 14, 1983·Biochemical and Biophysical Research Communications·F A Fitzpatrick, D Stringfellow
Jan 1, 1986·Journal of Free Radicals in Biology & Medicine·U N DasD F Horrobin
Jun 14, 1983·The American Journal of Medicine·A K Done
Oct 31, 1983·Biochemical and Biophysical Research Communications·M G SantoroM Esteban
Apr 24, 2003·Medicinal Research Reviews·Raffaele SaladinoAnna Teresa Palamara
Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·I M KerrM Knight

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