Establishment of Theileria-infected bovine cell lines in scid mice

Parasite Immunology
A H FellJ D Ansell

Abstract

Bovine cells transformed by infection with the protozoan parasite Theileria annulata were inoculated subcutaneously or intraperitoneally into C.B.-17 scid mice. Mice injected subcutaneously developed solid tumours at the injection site, whilst those injected intraperitoneally developed ascites. Schizont-infected cells were found in other tissues: infected cells spread much more easily from the intraperitoneal site. Karyotyping of cells isolated from tumours showed no evidence of transfer of parasites to murine cells. These results show that the scid mouse can be used as a host for Theileria-infected bovine cells.

References

Dec 23, 1988·Science·R NamikawaJ M McCune

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Citations

Feb 1, 1993·International Journal for Parasitology·A H Fell, P M Preston
Nov 1, 1993·Parasitology Today·S L Stanley, H W Virgin
Aug 1, 1990·Parasitology·G F MitchellW U Tiu
Sep 1, 1979·Australian Veterinary Journal·M Nunn, R H Johnson
Feb 10, 1995·Science·O K ole-MoiYoi
Jul 25, 2000·Clinical Microbiology Reviews·M J HomerD H Persing
May 3, 2013·PLoS Pathogens·Justine MarsolierJonathan B Weitzman
Apr 21, 2005·Cellular Microbiology·Martin BaumgartnerGordon Langsley
Nov 5, 1999·Annual Review of Microbiology·D Dobbelaere, V Heussler
Nov 24, 1999·Infection and Immunity·M F MoreauG Langsley

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