Ester bonds in prodrugs

ACS Chemical Biology
Luke D Lavis

Abstract

A recent study challenges the oft-held notion that ester bonds in prodrug molecules are cleaved rapidly and completely inside cells by endogenous, nonspecific esterases. Structure-activity relationship studies on acylated sugars reveal that regioisomeric compounds display disparate biological activity, suggesting that ester bonds can persist in a cellular context.

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Citations

Sep 12, 2012·Journal of Medicinal Chemistry·Kung-Cheng LiuChi-Huey Wong
Mar 31, 2009·Journal of Medicinal Chemistry·Noha ElmouelhiKevin J Yarema
May 8, 2010·Chemical Communications : Chem Comm·Nan DaiEric T Kool
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Aug 14, 2009·Glycobiology·Jian DuKevin J Yarema
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Jul 23, 2011·Bioorganic & Medicinal Chemistry·Kung-Cheng LiuChi-Huey Wong
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