PMID: 11330469May 2, 2001Paper

Ester hydrolysis with 2,6-di(pyrazol-3-yl)pyridines and their CoII complexes in homogeneous and micellar media

Journal of Inorganic Biochemistry
R JairamP G Potvin

Abstract

The 1:1 complex of Co(ClO4)2 with the H2O-insoluble tridentate 2,6-di(1H-4,5,6,7-tetrahydroindazol-3-yl)pyridine (H21) was found to be an excellent catalyst for the hydrolysis of para-nitrophenyl acetate in aqueous buffers over the pH 7.05-7.90 range, with an estimated second-order rate constant of 0.50 M(-1) s(-1). The Co2+ complexes of the N,N'-di-1-dodecyl analogue in micellar media and the N,N'-di-(4-carboxyphenyl) analogue in aqueous media were much poorer catalysts, poorer than the free ligands. In all cases, the pH-rate profiles indicated that free base, deprotonated or hydroxo forms were the active species. The greater success with Co(H(2)1)2+ indicated a catalytic role for N-H deprotonation.

References


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Feb 4, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Li-Li MiaoJian-Ping Lang

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