Esterase-Sensitive and pH-Controlled Carbon Monoxide Prodrugs for Treating Systemic Inflammation

Journal of Medicinal Chemistry
Xingyue JiB Wang

Abstract

A bottleneck for developing CO-based therapeutics is the lack of a safe and controllable delivery form. Herein, we describe efforts toward organic CO prodrugs with dual-responsive endogenous triggers. One representative CO prodrug showed significant anti-inflammatory effects both in vitro and in a LPS-simulated systemic inflammation model. These results firmly establish such CO prodrugs as either research tools or candidate compounds for the treatment of systemic inflammation or inflammation related organ injuries.

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Citations

Dec 11, 2019·Medicinal Research Reviews·Xiaoxiao YangBinghe Wang
Aug 18, 2020·Medicinal Research Reviews·Xiaoxiao YangBinghe Wang
Jul 19, 2020·Antioxidants·Angeles ArocaLuis C Romero
Mar 2, 2021·Acta Pharmaceutica Sinica. B·Dominik BakalarzMarcin Magierowski
Oct 23, 2020·Chemical Reviews·Christopher P HopperBinghe Wang
Sep 16, 2020·Accounts of Chemical Research·Livia S LazarusLisa M Berreau

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