Esthesioneuroblastoma: A Patterns-of-Care and Outcomes Analysis of the National Cancer Database

Neurosurgery
Andrew OrtonYing J Hitchcock

Abstract

The available literature to guide treatment decision making in esthesioneuroblastoma (ENB) is limited. To define treatment patterns and outcomes in ENB according to treatment modality using a large national cancer registry. This study is a retrospective cohort analysis of 931 patients with a diagnosis of ENB who were treated with surgery, radiation therapy, and/or chemotherapy in the United States between the years of 2004 and 2012. Log-rank statistics were used to compare overall survival by primary treatment modality. Logistic regression modeling was used to identify predictors of receipt of postoperative radiotherapy (PORT). Cox proportional hazards modeling was used to determine the survival benefit of PORT. Subgroup analyses identified subgroups that derived the greatest benefit of PORT. Primary surgery was the most common treatment modality (90%) and resulted in superior survival compared to radiation (P < .01) or chemotherapy (P < .01). On multivariate analysis, PORT was associated with decreased risk of death (hazard ratio [HR] 0.53, P < .01). PORT showed a survival benefit in Kadish stage C (HR 0.42, P < .01) and D (HR 0.09, P = .01), but not Kadish A (HR 1.17, P = .74) and B (HR 1.37, P = .80). Patients who received c...Continue Reading

References

Sep 1, 1979·Cancer·D ElkonW C Constable
Aug 1, 1992·The Laryngoscope·P Dulguerov, T Calcaterra
Mar 1, 1989·American Journal of Public Health·S Greenland
Sep 1, 1988·International Journal of Radiation Oncology, Biology, Physics·C A SpauldingF M Stewart
Nov 15, 1993·International Journal of Radiation Oncology, Biology, Physics·R L FooteW M O'Fallon
May 1, 1993·Neurosurgery·A MoritaL M Quast
Nov 1, 1996·The Journal of Laryngology and Otology·N J SlevinW T Farrington
Sep 24, 2002·International Journal of Radiation Oncology, Biology, Physics·Günther GruberRichard Greiner
Jan 17, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Peter IngeholmDorthe Francis
May 10, 2003·Acta Oto-laryngologica·Sune A TheilgaardHanne Sand Hansen
Jan 18, 2005·Head & Neck·Eduardo M DiazFranco DeMonte
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Phyllis A GimottyDupont Guerry
Mar 8, 2006·Japanese Journal of Clinical Oncology·Shyh-An YehEng-Yen Huang
Jul 18, 2008·Journal of Neuro-oncology·Alyx B PorterJan C Buckner
Sep 18, 2008·Head & Neck·Gideon BacharJonathan C Irish
May 20, 2009·Statistics in Medicine·Ian R White, Patrick Royston
Dec 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard L GundersonAndrew Stewart
Mar 17, 2010·International Journal of Radiation Oncology, Biology, Physics·Mahmut OzsahinAbderrahim Zouhair
Jun 8, 2011·Brain : a Journal of Neurology·Jonathan W BartlettJames R Carpenter
Jun 12, 2013·Oral Oncology·A ModestoN Daly-Schveitzer
Sep 18, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michelle Kang KimJuan P Wisnivesky
Nov 25, 2014·Current Oncology Reports·Rami E SaadeDiana Bell
Nov 13, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Zhen-zhen YinYe-xiong Li
Feb 13, 2016·The Laryngoscope·Victoria E BanuchiLuc G T Morris
Jul 22, 2016·Statistics in Medicine·Lauren J BeesleyJeremy M G Taylor

❮ Previous
Next ❯

Citations

Apr 15, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Mark A ArnoldMitchell R Gore
Jan 29, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Gino Amleto PacinoSpinato Giacomo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved