Esthesioneuroblastoma with distant metastases: Systematic review & meta-analysis

Head & Neck
John P MarinelliAshish V Chintakuntlawar

Abstract

The purpose of this study was to determine the clinical outcomes and review the management strategies for metastatic esthesioneuroblastoma. We conducted a systematic review and meta-analysis. Forty-eight studies totaling 118 patients met inclusion criteria. Chemotherapy in combination with surgery and/or radiation exhibited the best overall survival when compared to monotherapy and no treatment (P < .001). However, most patients (66%) received either monotherapy or no therapy. The number and location of metastases among the 3 treatment groups did not significantly differ (P = .85). Treatment modality remained significantly associated with overall survival on multivariable analysis (P < .001). Platinum-based chemotherapy was most commonly utilized but did not provide a survival benefit when compared with all other regimens (P = .88). Distant metastases with esthesioneuroblastoma portend a poor prognosis. Chemotherapy in combination with surgery and/or radiation was associated with improved overall survival. Further research into the optimal systemic therapeutic regimen for patients with distant metastases is critical.

References

May 1, 1993·Neurosurgery·A MoritaL M Quast
Aug 1, 1996·American Journal of Clinical Oncology·A P JekunenM J Kajanti
Nov 1, 1996·The Journal of Laryngology and Otology·N J SlevinW T Farrington
Jan 1, 1997·Heart·T ChatterjeeB Meier
Oct 16, 1999·The Laryngoscope·P A LevineR W Cantrell
Aug 15, 2000·Head & Neck·V A RestoW H Westra
Oct 3, 2000·British Journal of Neurosurgery·G ChackoM J Chandy
Feb 13, 2001·International Journal of Radiation Oncology, Biology, Physics·H T EichR Müller
Mar 21, 2002·The Lancet Oncology·P DulguerovT C Calcaterra
Jul 19, 2002·Cancer·Marc C Chamberlain
Sep 21, 2002·Journal of Neuro-oncology·Sung-Kyun HwangHee-Won Jung
Jun 17, 2003·Head & Neck·Alan T MonroeWilliam M Mendenhall
Nov 7, 2003·The Laryngoscope·Alfio FerlitoPeter H Rhys-Evans
May 13, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jannis ConstantinidisHeinrich Iro
Aug 30, 2005·Acta Cytologica·Karima MradKhaled Ben Romdhane
Nov 26, 2005·Neurologia Medico-chirurgica·Mamoru MurakamiYouhei Hosokawa
Feb 24, 2006·Archives of Otolaryngology--head & Neck Surgery·Andrew H LoyPaul A Levine
Mar 21, 2007·Archives of Otolaryngology--head & Neck Surgery·Daniel JethanamestDavid I Kutler
Mar 4, 2008·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Hyun Jik KimJoo-Heon Yoon
Jul 22, 2008·The Laryngoscope·Nikolaos TselisNikolaos Zamboglou
Sep 23, 2008·The Spine Journal : Official Journal of the North American Spine Society·Paul M ArnoldKaren K Anderson
Feb 26, 2009·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Anthony C NicholsDerrick T Lin
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Feb 19, 2011·Indian Journal of Cancer·B RaiK Dimri
Mar 16, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Leif BäckAntti A Mäkitie
Jun 17, 2011·International Journal of Radiation Oncology, Biology, Physics·Candan DemirozAvraham Eisbruch
Aug 2, 2011·Journal of Neurosurgery. Spine·Abigail J RaoBrian T Ragel
Jan 1, 2011·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Mitchell R Gore, Adam M Zanation
Sep 8, 2012·Neurology India·Pradipta TripathySureswar Mohanty
Oct 17, 2012·The Laryngoscope·Chang Myeon SongChae-Seo Rhee
Nov 28, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ritesh KumarSuresh Chander Sharma
Jun 5, 2013·Journal of Neurological Surgery. Part B, Skull Base·Snehal G PatelJatin P Shah
Jun 20, 2013·Head & Neck·Thomas J OwMichael E Kupferman
Oct 2, 2013·Journal of Neurological Surgery. Part B, Skull Base·Jamie J Van GompelMichael J Link
Mar 27, 2015·British Journal of Neurosurgery·Sandeep MohindraBishan D Radotra
Oct 16, 2015·The Journal of Craniofacial Surgery·Leyla NiyazDuygu Kankaya
Oct 31, 2015·Pediatric Blood & Cancer·Rajkumar VenkatramaniMurali Chintagumpala
Feb 13, 2016·The Laryngoscope·Victoria E BanuchiLuc G T Morris
Sep 15, 2016·Surgical Neurology International·Masatoshi YunokiKimihiro Yoshino

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Citations

Sep 19, 2019·Case Reports in Oncological Medicine·Inês Maria GuerreiroJosé Dinis
Feb 2, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Olfat Kamel HasanRodney J Hicks

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