PMID: 11318314Apr 25, 2001Paper

Estimate of absorbed dose based on two-dimensional autoradiographic information in internal radionuclide therapy

Medical Physics
X Q LuL M Chin

Abstract

In radiation therapies using radionuclides emitting short-range particles, such as radioimmunotherapy or boron neutron capture therapy, the biological effects are strongly affected by the heterogeneity of the absorbed dose distribution delivered to tumor cells. The three-dimensional (3D) information of the source distribution at the cellular level is required to accurately determine the absorbed dose distribution to the individual tumor cells. Two-dimensional distribution of cell and nuclide with a resolution of 1 microm can be obtained from individual tissue sections by microautoradiography. To obtain such information in 3D, an ideal approach would be to align the serial tissue sections from a block and analyze all of them. This is straightforward in theory, but extremely difficult in practice. Furthermore, every section in the block has to be processed and analyzed, and the usage of the data from this laborious work is very inefficient. An approach presented here is to estimate the absorbed dose based on individual sections without 3D reconstruction. It is realistically workable since it avoids the most difficult task of alignment for the serial tissue sections. In addition, the absorbed dose can be estimated based on a limit...Continue Reading

References

Jan 1, 1989·Leukemia Research·L M CobbJ Humphreys
Feb 24, 1999·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·M G StabinS E Strand
Aug 6, 1999·Medical Physics·T K JohnsonS McCourt
Aug 6, 1999·Medical Physics·T K JohnsonS McCourt

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Citations

Sep 5, 2003·Cancer Biotherapy & Radiopharmaceuticals·A MalarodaR J Ott
Oct 23, 2012·Radiological Physics and Technology·Satoru UtsunomiyaMasahiro Hiraoka
Feb 6, 2007·Radiation Protection Dosimetry·X-Q Lu, W S Kiger

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