Estimated glomerular filtration rate for longitudinal follow-up of living kidney donors

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Marco van LondenMartin H de Borst

Abstract

Living kidney donor safety requires reliable long-term follow-up of renal function after donation. The current study aimed to define the precision and accuracy of post-donation estimated glomerular filtration rate (eGFR) slopes compared with measured GFR (mGFR) slopes. In 349 donors (age 51 ± 10, 54% female), we analysed eGFR according to the 2009 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, Modification of Diet in Renal Disease (MDRD) and Cockcroft-Gault/body surface area (CG/BSA), creatinine clearance (CrCl) and mGFR (125I-iothalamate) changes from 3 months until 5 years post-donation. Donors had a pre-donation mGFR of 116 ± 23 mL/min, at 3 months post-donation mGFR was 73  ± 14 mL/min and at 5 years it was 79 ± 16 mL/min. Between 3 months and 5 years post-donation, 28% of donors had a declining mGFR (-0.82 ± 0.79 mL/min/year), 47% were stable and 25% had an increasing mGFR. Overall, eGFR equations showed good slope estimates (bias eGFRCKD-EPI 0.13 ± 2.16 mL/min/year, eGFRMDRD 0.19 ± 2.10 mL/min/year, eGFRCG/BSA -0.08 ± 2.06 mL/min/year, CrCl -0.12 ± 4.75 mL/min/year), but in donors with a decreasing mGFR the slope was underestimated (bias eGFRCKD-EPI 1.41 ± 2.03 mL/min/year, eGFRMDRD 1.51 ± 1.96 mL/m...Continue Reading

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Citations

Apr 2, 2020·Transplantation·Guillaume ClaisseChristophe Mariat
Dec 20, 2020·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Pablo LujánWalter Douthat
Jun 26, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Pablo LujánWalter Douthat
Aug 5, 2021·Clinical Kidney Journal·Natalie EbertElke Schaeffner

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