Estimated Impact of Hepatitis C Positive Lung Donor Utilization on US Donor Lung Supply

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Joshua J MooneyGundeep S Dhillon

Abstract

The availability of highly effective direct-acting antiviral agent (DAA) medications for Hepatitis C virus (HCV) has led to reports of safely transplanting HCV+ donor lungs to HCV- candidates. However, it remains unclear how the ability to use HCV+ donor lungs for lung transplant could impact the number of donor lungs available for transplant. Using Scientific Registry of Transplant Recipient data we identified all deceased organ donors within the United States from March 1, 2015 to February 28, 2018 and stratified by HCV status. A donor prediction model for lung donation was derived and validated within HCV- donors and applied to HCV+ donors to estimate the number of acceptable HCV+ lung donors. Of 29,481 eligible donors, 2,054 (7.0%) were HCV+ donors with 82 HCV+ donors' lungs being utilized for transplant during the study period. The prediction model for donor lung donation (specificity 92.6%, sensitivity 65.6%) estimated 248 HCV+ donors (75 non-viremic, 173 viremic) were acceptable for lung transplant during the study period, suggesting that 166 acceptable HCV+ lung donors were discarded. The ability to transplant lungs from HCV+ organ donors would lead to an estimated nationwide increase of at least 55 donor lungs per year...Continue Reading

References

Jul 16, 2008·BMC Bioinformatics·Carolin StroblAchim Zeileis
Nov 23, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B KhanM Cypel
May 31, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J LevitskyM Volk
Jul 9, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C E KlingL Sibulesky
Jan 3, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M ValapourB L Kasiske
Feb 8, 2018·American Journal of Respiratory and Critical Care Medicine·Ahmed AbdelbasitKaren Doucette
Mar 30, 2018·American Journal of Speech-language Pathology·Charles R GreenwoodJudith J Carta
May 17, 2018·The New England Journal of Medicine·Mandeep R MehraJosef Stehlik
Feb 28, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M ValapourB L Kasiske
Apr 5, 2019·The New England Journal of Medicine·Ann E WoolleyUNKNOWN DONATE HCV Trial Team

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Citations

May 25, 2021·The Journal of Thoracic and Cardiovascular Surgery·Michael LanutiBryan M Burt
Jun 2, 2021·The Annals of Thoracic Surgery·Selena S LiMasaki Funamoto

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