Estimated impact of LDCT-identified stage IA non-small-cell lung cancer on screening efficacy

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
J M Reich

Abstract

About one-third of individuals radiographically diagnosed with surgical-pathological stage IA non-small-cell lung cancer (IA-NSCLC) harbor occult metastases that prove lethal. A comparison of the projected outcome of CT-diagnosed IA-NSCLC with actuarial figures for life expectancy of screenees suggests that about half of the remainder will succumb to alternative causes. CT screening can be efficacious if and only if it leads to an interdiction of potentially lethal cancers in the remaining one-third of sufficient magnitude that it offsets the surgical mortality and abbreviation of life expectancy in the two-thirds who are either understaged or overdiagnosed. Preliminary evidence from CT screening trials fails to support the premise that it diminishes the absolute number of advanced lung cancers.

References

Aug 1, 1986·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·R S FontanaJ R Muhm
Jun 16, 1993·Journal of the National Cancer Institute·B W BrownM C Minnotte
Oct 18, 2000·JAMA : the Journal of the American Medical Association·T L Petty
Feb 24, 2001·The British Journal of Radiology·M HasegawaT Watanabe
Jan 15, 2003·JAMA : the Journal of the American Medical Association·Parthiv J MahadeviaNeil R Powe
Feb 26, 2003·Radiology·Stephen J SwensenMedy A Clemens
Mar 1, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Claudia I HenschkeOlli S Miettinen
Jul 13, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·William L ReadRamaswamy Govindan
Dec 18, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·John K GohaganUNKNOWN LUNG SCREENING STUDY RESEARCH GROUP
Feb 8, 2005·Radiology·Stephen J SwensenKatie L Allen

❮ Previous
Next ❯

Citations

Jan 26, 2011·The Cancer Journal·Susan C Van't Westeinde, Rob J van Klaveren

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Gary YauGeorge Rodrigues
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Maurizio InfanteDANTE Study Group
Chest
Peter B BachAmerican College of Chest Physicians
© 2022 Meta ULC. All rights reserved