Estimated impact of rotavirus vaccine on hospitalizations and deaths from rotavirus diarrhea among children <5 in Asia

Expert Review of Vaccines
Eleanor BurnettU D Parashar

Abstract

Of the 215,000 global deaths from rotavirus estimated in 2013, 41% occur in Asian countries. However, despite a recommendation for global rotavirus vaccination since 2009, only eight countries in Asia have introduced the rotavirus vaccine into their national immunization program as of September 2017. To help policy makers assess the potential value of vaccination, we projected the reduction in rotavirus hospitalizations and deaths following a hypothetical national introduction of rotavirus vaccines in all countries in Asia using data on national-level rotavirus mortality, <5 population, rotavirus hospitalizations rates, routine vaccination coverage, and vaccine effectiveness. To quantify uncertainty, we generated 1,000 simulations of these inputs. Our model predicted 710,000 fewer rotavirus hospitalizations, a 49% decrease from the 1,452,000 baseline hospitalizations and 35,000 fewer rotavirus deaths, a 40% decrease from the 88,000 baseline deaths if all 43 Asian countries had introduced rotavirus vaccine. Similar reductions were projected in subanalyses by vaccine introduction status, subregion, and birth cohort size. Rotavirus vaccines will substantially reduce morbidity and mortality due to rotavirus infections in Asia.

References

Aug 6, 1998·Epidemiology and Infection·P K ChanA F Cheng
Aug 10, 2005·The Journal of Infectious Diseases·Rajiv BahlUNKNOWN Delhi Rotavirus Study Group
Aug 10, 2005·The Journal of Infectious Diseases·E Anthony S NelsonRoger I Glass
Aug 10, 2005·The Journal of Infectious Diseases·Vincent P HsuJoseph Bresee
Jan 6, 2006·The New England Journal of Medicine·Guillermo M Ruiz-PalaciosUNKNOWN Human Rotavirus Vaccine Study Group
Jan 6, 2006·The New England Journal of Medicine·Timo VesikariUNKNOWN Rotavirus Efficacy and Safety Trial (REST) Study Team
Jan 6, 2006·The Pediatric Infectious Disease Journal·Dang Duc AnhRoger I Glass
Apr 9, 2008·Expert Review of Vaccines·Lucia Helena de OliveiraJon Kim Andrus
Oct 13, 2009·The Journal of Infectious Diseases·Celia C CarlosMarc-Alain Widdowson
Oct 13, 2009·The Journal of Infectious Diseases·Elmira T FlemRichard D Rheingans
Nov 26, 2009·Vaccine·Jacqueline E TateGagandeep Kang
Nov 3, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jin-Tu LouMei-Qin Tong
Jan 12, 2011·The Pediatric Infectious Disease Journal·Lucia Helena de OliveiraJon Kim Andrus
Apr 29, 2011·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Renat LatipovElmira Flem
Aug 21, 2013·The Pediatric Infectious Disease Journal·Kong Boo PhuaYanfang Liu
Aug 6, 2014·Vaccine·Nita BhandariUNKNOWN India Rotavirus Vaccine Group
Mar 24, 2016·The Pediatric Infectious Disease Journal·Tharani LoganathanMark Jit
Apr 10, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jacqueline E TateUNKNOWN World Health Organization–Coordinated Global Rotavirus Surveillance Network
Sep 7, 2016·Vaccine·Karene Hoi Ting YeungE Anthony S Nelson
Mar 23, 2017·The New England Journal of Medicine·Sheila IsanakaRebecca F Grais
Apr 12, 2017·Vaccine·Carl D KirkwoodA Duncan Steele
Apr 22, 2017·The Journal of Infectious Diseases·Eleanor BurnettUmesh D Parashar
Apr 27, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christine L JonestellerUmesh D Parashar

❮ Previous
Next ❯

Citations

Feb 9, 2019·Human Vaccines & Immunotherapeutics·A D SteeleC D Kirkwood
Feb 14, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Duncan Steele, Umesh D Parashar
Jul 16, 2019·Current Opinion in Infectious Diseases·Rachel M BurkeUmesh D Parashar
Feb 26, 2020·The Journal of Infectious Diseases·Eleanor BurnettJacqueline E Tate
Jun 17, 2020·Expert Review of Vaccines·Benjamin D HallowellUmesh Parashar
Jul 2, 2020·Vaccines·Olufemi Samuel Folorunso, Olihile M Sebolai
Jan 16, 2019·JAMA Network Open·Carl D Kirkwood, A Duncan Steele
Nov 23, 2019·The Journal of Infectious Diseases·Eleanor BurnettUmesh D Parashar
Jul 6, 2021·Virus Research·Sarah CaddyUlrich Desselberger
Aug 23, 2020·The Lancet Global Health·Eleanor BurnettJacqueline E Tate
Aug 11, 2021·The Journal of Infectious Diseases·Rachel M BurkeUmesh D Parashar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.