Jun 2, 2020

Estimated Sp02/Fio2 ratio to predict mortality in patients with suspected COVID-19 in the Emergency Department: a prospective cohort study

MedRxiv : the Preprint Server for Health Sciences
Johannes von Vopelius-FeldtJ. Cameron


Background This study examined whether the presence and severity of Type 1 Respiratory Failure (T1RF), as measured by the ratio of pulse oximetry to estimated fraction of inspired oxygen (SpO2/eFiO2 ratio), is a predictor of in-hospital mortality in patients presenting to the ED with suspected COVID19 infection. Methods We undertook a prospective observational cohort study of patients admitted to hospital with suspected COVID-19 in a single ED in England. We used univariate and multiple logistic regression to examine whether the presence and severity of T1RF in the ED was independently associated with in-hospital mortality. Results 180 patients with suspected COVID19 infection met the inclusion criteria for this study, of which 39 (22%) died. Severity of T1RF was associated with increased mortality with odds ratios (OR) and 95% confidence intervals of 1.58 (0.49 to 5.14), 3.60 (1.23 to 10.6) and 18.5 (5.65 to 60.8) for mild, moderate and severe T1RF, respectively. After adjusting for age, gender, pre-existing cardiovascular disease, neutrophil-lymphocyte ration (NLR) and estimated glomerular filtration rate (eGFR), the association remained, with ORs of 0.63 (0.13 to 3.03), 3.95 (0.94 to 16.6) and 45.8 (7.25 to 290). The results...Continue Reading

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Mentioned in this Paper

Prospective Cohort Study
Prognostic Factor
Cardiovascular Diseases
Hospital Admission
Death (Finding)
YjgI protein, E coli
Oximetry, Pulse
Accident and Emergency Department

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