PMID: 3752237Sep 1, 1986Paper

Estimates of activation in arterial smooth muscle

The American Journal of Physiology
H A SingerR A Murphy

Abstract

We have previously described the onset of a "latch" state in the swine carotid media after K+ depolarization. This state was characterized by maintained stress after a decrease in shortening velocities and in the level of cross-bridge phosphorylation. The present experiments were designed to determine whether there were changes in other mechanical properties in swine carotid media associated with the onset of the latch state. Medial strips (less than 500 microM thick), incubated in physiological salt solution (PSS) at 37 degrees C at their optimal length (Lo), were subjected to ramp stretches (5.86 mm/s) of 5% Lo. The active stress (Sa) response to stretch was computed by subtraction of the passive element contribution (as determined from identical stretches after 30 min incubation in Ca2+-free PSS) from the total response in the activated muscle. Transitions in the total and active stress responses to stretch were observed in strips stimulated with 109 mM K+ for 1 min or longer and were interpreted as yielding of the contractile apparatus. Active dynamic stiffness (dS/dLo) calculated from the initial 1% Lo portion of the stretch response, correlated linearly with active stress over a wide range. Maximal stress and dynamic stif...Continue Reading

References

Mar 1, 1978·The Journal of Physiology·F W Flitney, D G Hirst
Nov 1, 1976·The American Journal of Physiology·T M ButlerR E Davies
Sep 1, 1973·Circulation Research·J T Herlihy, R A Murphy
Jun 1, 1974·The American Journal of Physiology·R A Meiss, E H Sonnenblick
Jun 1, 1974·The American Journal of Physiology·N L Stephens, C M Skoog
Aug 1, 1983·The Journal of General Physiology·D M Warshaw, F S Fay
Nov 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R W Mitchell, N L Stephens
Nov 1, 1980·The Journal of General Physiology·M J SiegmanR E Davies
Feb 1, 1981·The Journal of Physiology·L E FordR M Simmons

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Citations

Mar 1, 1987·Circulation Research·H A Singer, R A Murphy
May 21, 2004·American Journal of Physiology. Cell Physiology·Christopher M RemboldRichard A Murphy
Jun 1, 1993·Journal of Muscle Research and Cell Motility·C M Rembold, R A Murphy
May 15, 1997·The Journal of Physiology·C J WingardR A Murphy
May 1, 1997·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·R A MurphyJ D Strauss

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