PMID: 9664726Jul 17, 1998Paper

Estimates of the number of liver carcinogens in bioassays conducted by the National Toxicology Program

Risk Analysis : an Official Publication of the Society for Risk Analysis
K S CrumpY Wang

Abstract

Estimates were made of the numbers of liver carcinogens in 390 long-term bioassays conducted by the National Toxicology Program (NTP). These estimates were obtained from examination of the global pattern of p-values obtained from statistical tests applied to individual bioassays. Representative estimates of the number of liver carcinogens (90% confidence interval in parentheses) obtained in our analysis compared to NTP's determination are as follows: female rats--49 (23, 76), NTP = 30; male rats--88 (59, 116), NTP = 35; female mice--131 (105, 157), NTP = 81; male mice--100 (73, 126), NTP = 61; overall--166 (135, 197), NTP = 108. The estimator from which these estimates were obtained is biased low by an unknown amount. Consequently, this study provides persuasive evidence of the existence of more rodent liver carcinogens than were identified by the NTP.

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Citations

Feb 9, 2005·Regulatory Toxicology and Pharmacology : RTP·David W Gaylor
Aug 16, 2001·Critical Reviews in Toxicology·K Crump
Sep 12, 2006·Personality & Social Psychology Bulletin·Charlie L Hardy, Mark Van Vugt
Oct 3, 2009·Archives of Environmental Contamination and Toxicology·Keith E LevineBradley J Collins
May 29, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ivan RusynFred A Wright
Aug 21, 2020·Angewandte Chemie·Libor KovarikJanos Szanyi

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