Estimating demand and unmet need for allogeneic hematopoietic cell transplantation in the United States using geographic information systems

Journal of Oncology Practice
Kelsey L BesseEric P Williams

Abstract

Allogeneic hematopoietic cell transplantation (HCT) is an increasingly used therapy for many patients with hematologic malignancies and other marrow failure or immune system disorders. The purpose of this study was to quantify and visualize both the demand and unmet need for HCT. HCT use for 2012 was described using the Center for International Blood and Marrow Transplant Research registry. Potential demand for HCT was calculated using 2012 SEER data and published literature for HCT-treatable conditions. Point locations of transplant centers were geocoded using geographic information system (GIS) software; Thiessen polygons were created to establish adult (age 20 to 74 years) and pediatric (age 0 to 19 years) market areas. Market-area population estimates were calculated using 2012 population estimates by age aggregated by census block. US market areas for HCTs were identified separately for transplant centers treating adult (n = 62) and pediatric patients (n = 52). Overall HCT demand among adults was 16,096, with an unmet need for HCTs of 10,276 patients. For pediatric patients, the total demand was 4,561, with an unmet need of 3,213 potential recipients. Evaluation of adult and pediatric market areas indicated that the larges...Continue Reading

References

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Citations

Sep 26, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kelsey BesseMark Albrecht
Oct 13, 2015·Bone Marrow Transplantation·P L Delamater, J P Uberti
Nov 16, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nandita KheraNavneet Majhail

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