Estimating glomerular filtration rate in children at serial follow-up when height is unknown.

Clinical Journal of the American Society of Nephrology : CJASN
Michael ZappitelliBethany J Foster

Abstract

Estimation of GFR in children from serum creatinine measures in regional databases is limited by a lack of height data. Furthermore, the ability of GFR estimating equations to quantify changes in GFR over time is unknown. Two methods of estimating GFR when height is unknown and the ability of several GFR equations to quantify GFR changes over time were evaluated. This retrospective study included 195 children (mean age 11.9 ± 4.6 years, GFR = 78.8 ± 34.5) who underwent iothalamate GFR, serum creatinine, and height measurements; 93 children underwent a second GFR measurement and 47 a third GFR measurement. Four equations were evaluated for bias and precision and for quantifying GFR change over time: (1) Schwartz, using measured height; (2) Schwartz, using estimated height (based on previous height percentile); (3) a locally derived modification of a previously derived height-independent equation. The Schwartz (measured height) displayed the least bias (-2 to +7%), followed by the modified height-independent equation and Schwartz (estimated height). All equations were imprecise. All equations performed similarly at capturing change in measured GFR over time, with no significant difference between estimated and measured GFR percen...Continue Reading

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Citations

Jan 19, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hans PottelFrank Martens
Feb 11, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Aram Ben VrolingYolanda Brigitta de Rijke
Sep 24, 2013·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·R Montañés BermúdezUNKNOWN miembros de la Comisión de Función Renal de la Sociedad Española de Bioquímica Clínica y Patología Molecular (SEQC)
Mar 5, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hans PottelPierre Delanaye
Apr 12, 2016·Congenital Heart Disease·Jason F GoldbergJack F Price
Apr 10, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nikki Rink, Michael Zappitelli
Apr 27, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hans Pottel
Aug 29, 2017·Pediatric Research·Omar AlkandariRulan S Parekh
Sep 20, 2019·Pediatric Research·Erika R O'NeilAndrea T Cruz
Feb 1, 2017·Indian Pediatrics·Himesh BarmanSourabh Gohain Duwarah
Oct 31, 2017·Journal of Paediatrics and Child Health·Carolina C Llanos-PaezStefanie Hennig

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