Estimating glomerular filtration rate in the general population: the second Health Survey of Nord-Trondelag (HUNT II)

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Stein HallanStian Lydersen

Abstract

Guidelines recommend the modification of diet in the renal disease (MDRD) formula or the Cockcroft-Gault formula for estimating the glomerular filtration rate (GFR). However, there is an ongoing discussion whether the MDRD formula should be used in the general population as several studies have found a large underestimation of its GFR estimates. In this study, 1,029 low-risk subjects, eligible for kidney donation according to internationally accepted criteria were selected from the population-based second Health Survey of Nord-Trondelag (HUNT II). Serum creatinine values traceable to isotope dilution mass spectrometry were used with the re-expressed MDRD formula recently published. The 2.5th, 50th and 97.5th percentiles of GFR by age were calculated and compared to reference values from the literature, which are based on GFR measured with gold standard methods in potential kidney donors. The difference between the 50th percentiles for MDRD estimates and measured GFR in the literature was small and constant over age: +0.5 ml/min/1.73 m(2) at age 20 and -2.0 ml/min/1.73 m(2) at age 80. Bias for Cockcroft-Gault estimates varied from 0.0 ml/min/1.73 m(2) to -21.4 ml/min/1.73 m(2). Other formulae also had a too steep age correction,...Continue Reading

References

May 1, 1979·Clinical Pharmacokinetics·T D Bjornsson
Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Jun 1, 1988·The American Journal of Medicine·D E Salazar, G B Corcoran
Mar 1, 1985·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G F Gates
Apr 12, 2000·Nuclear Medicine Communications·D HamiltonA al Khader
Feb 24, 2001·British Journal of Cancer·J G WrightA H Calvert
Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Josef CoreshAndrew S Levey
Jan 9, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrew D RuleTimothy S Larson
Jun 24, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Stein HallanHarald Johnsen
Dec 18, 2004·Nuclear Medicine Communications·Gurmandeep S Grewal, Glen M Blake
Dec 22, 2004·Annals of Internal Medicine·Lesley A Stevens, Andrew S Levey
Jan 22, 2005·Journal of the American Society of Nephrology : JASN·Marc FroissartPascal Houillier
Jul 7, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Massimo CirilloNatale G De Santo

❮ Previous
Next ❯

Citations

Apr 11, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jens KronborgTrond Jenssen
Jul 7, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·John MunkhaugenStein Hallan
Jan 30, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eelg-You Park, Think-You Kim
Jul 6, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stein Ivar Hallan, Stephan Reinhold Orth
Aug 9, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rune BjørneklettBjarne M Iversen
Jul 18, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pierre DelanayeOlivier Moranne
Jun 20, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stein I Hallan, Ron T Gansevoort
Nov 2, 2006·Current Opinion in Critical Care·Eric A J Hoste, John A Kellum
Apr 15, 2008·Current Opinion in Nephrology and Hypertension·Stein Ivar Hallan, Bjørn Egil Vikse
Aug 14, 2009·Nephrology·Xuefeng SunXiujuan Liu
Apr 10, 2009·Journal of the American Society of Nephrology : JASN·Stein I HallanStephan R Orth
Oct 12, 2010·European Journal of Endocrinology·Bjørn Olav AsvoldLars J Vatten
Jul 15, 2009·Néphrologie & thérapeutique·C Loos-AyavUNKNOWN pour le comité de pilotage EPIRAN
Nov 21, 2008·Postgraduate Medicine·Ahmed H AbdelhafizMeguid El Nahas
Jan 5, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Kristin M AakreSverre Sandberg
Jan 26, 2016·Soins. Gérontologie·Isabelle Segalen, Yannick Le Meur
May 23, 2008·Kidney International·Nynke HalbesmaUNKNOWN PREVEND study group
Aug 16, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tazeen H JafarAndrew S Levey
May 5, 2010·Advances in Chronic Kidney Disease·Rajiv SaranVahakn Shahinian
Mar 21, 2009·Clinical Biochemistry·Larry H BernsteinJohn F Heitner
Dec 25, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Julie R Ingelfinger
Nov 27, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Elizabeth SelvinJosef Coresh
Jun 23, 2006·Journal of the American Society of Nephrology : JASN·Stein I HallanJostein Holmen
Feb 11, 2014·Journal of the American Society of Nephrology : JASN·Antonello PaniFrancesco Cucca
Jul 9, 2009·Interactive Cardiovascular and Thoracic Surgery·Claudius DiezHans-Stefan Hofmann
Apr 24, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christiaan L MeuweseUNKNOWN Thyroid Studies Collaboration

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.