Estimating implant survival in the presence of competing risks.

International Orthopaedics
David Jean Biau, Moussa Hamadouche

Abstract

In medical research, commonly, one is interested in the time to the occurrence of a particular event, such as the revision of an implant, and the analysis of these data is referred to as survival analysis. However, for some patients, the event is not observed and their observations are censored. These censored observations are particular to survival data and require specific methods for estimation. The Kaplan and Meier method is a popular method to estimate the probability of being free of the event over time and it is now widely applied in orthopaedics such as to report implant survival. However, one of the assumptions underlying the Kaplan-Meier estimator implies that patients whose observations are censored have the same risk of occurrence of the event than patients remaining in the study. However, because the revision of an implant cannot occur after a patient dies, and that dead patients have their observations censored in the Kaplan-Meier method, another setting must be considered. In the sequel we will demonstrate the inadequacy of the Kaplan-Meier method to estimate implant survival and detail the cumulative incidence estimator.

References

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Citations

Jan 19, 2011·International Orthopaedics·Jean-Pierre Courpied, Jacques Henri Caton
Mar 12, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Guillaume RiouallonStéphane Wolff
Mar 26, 2015·Clinical Orthopaedics and Related Research·Sarah LacnyDeborah A Marshall
Sep 27, 2015·Clinics in Podiatric Medicine and Surgery·Annette F P Bartel, Thomas S Roukis
May 29, 2014·Clinical Orthopaedics and Related Research·Reinhard SchuhPhilipp T Funovics
Apr 8, 2016·The Journal of Bone and Joint Surgery. American Volume·Hilal Maradit KremersDaniel J Berry
Nov 16, 2019·Bone & Joint Research·Y KurodaH Akiyama
Jan 3, 2014·The Journal of Bone and Joint Surgery. American Volume·Valérie ZellerPatrick Mamoudy

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