Estimating lumbar passive stiffness behaviour from subject-specific finite element models and in vivo 6DOF kinematics.

Journal of Biomechanics
Christian AffolterA K Aiyangar

Abstract

Passive rotational stiffness of the osseo-ligamentous spine is an important input parameter for estimating in-vivo spinal loading using musculoskeletal models. These data are typically acquired from cadaveric testing. Increasingly, they are also estimated from subject-specific imaging-based finite element (FE) models, which are typically built from CT/MR data obtained in supine position and employ pure rotation kinematics. We explored the sensitivity of FE-based lumbar passive rotational stiffness to two aspects of functional in-vivo kinematics: (a) passive strain changes from supine to upright standing position, and (b) in-vivo coupled translation-rotation kinematics. We developed subject-specific FE models of four subjects' L4L5 segments from supine CT images. Sagittally symmetric flexion was simulated in two ways: (i) pure flexion up to 12° under a 500 N follower load directly from the supine pose. (ii) First, a displacement-based approach was implemented to attain the upright pose, as measured using Dynamic Stereo X-ray (DSX) imaging. We then simulated in-vivo flexion using DSX imaging-derived kinematics. Datasets from weight-bearing motion with three different external weights [(4.5 kg), (9.1 kg), (13.6 kg)] were used. Acc...Continue Reading

References

Jan 11, 1976·Journal of Biomechanics·M M PanjabiA A White
Dec 1, 1991·Biomedizinische Technik. Biomedical Engineering·L P Nolte, T H Pingel
Feb 1, 1987·Journal of Biomechanical Engineering·W T EdwardsR W Mann
Nov 1, 1987·Journal of Biomechanical Engineering·V K GoelY E Kim
Jan 1, 1986·Journal of Biomechanics·A Shirazi-AdlS C Shrivastava
Mar 1, 1994·The Journal of Bone and Joint Surgery. American Volume·M M PanjabiJ J Crisco
Oct 26, 2000·Clinical Biomechanics·A Shirazi-Adl, M Parnianpour
Apr 6, 2002·Journal of Biomechanics·Ian A StokesJeffrey P Laible
Oct 9, 2002·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·M J FaganA M Mohsen
Apr 23, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Avinash G PatwardhanOdysseas Paxinos
Apr 23, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mack G Gardner-Morse, Ian A Stokes
Jan 7, 2004·Journal of Biomechanics·Mack G Gardner-Morse, Ian A F Stokes
Mar 10, 2006·Journal of Biomechanics·Frank HeuerHans-Joachim Wilke
Oct 24, 2013·Journal of Biomechanical Engineering·Ameet K AiyangarZhang Xudong
Dec 19, 2013·Clinical Biomechanics·Shaobai WangGuoan Li
Apr 30, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Minfei WuGuoan Li
May 16, 2014·Journal of Biomechanical Engineering·Ameet K AiyangarHeidi-Lynn Ploeg
Oct 18, 2015·Journal of Biomechanics·Idsart KingmaJaap H van Dieën
May 14, 2016·Biomechanics and Modeling in Mechanobiology·F GhezelbashA Plamondon
Nov 17, 2016·Computer Methods in Biomechanics and Biomedical Engineering·Sadegh Naserkhaki, Marwan El-Rich
May 22, 2017·Journal of Biomechanics·F AzariT Rahimi-Moghaddam
Nov 4, 2017·Journal of Biomechanics·Ryan M ByrneXudong Zhang
Feb 5, 2019·Computer Methods in Biomechanics and Biomedical Engineering·Erica Beaucage-GauvreauClaire F Jones

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.