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Estimating missing heritability for disease from genome-wide association studies

American Journal of Human Genetics

Mar 8, 2011

Sang Hong LeePeter M Visscher

Abstract

Genome-wide association studies are designed to discover SNPs that are associated with a complex trait. Employing strict significance thresholds when testing individual SNPs avoids false positives at the expense of increasing false negatives. Recently, we developed a method for quantita...read more

Mentioned in this Paper

Genome-Wide Association Study
In Silico
IIeocolitis
Genome
Dysequilibrium Syndrome
Chromosomes, Human, Pair 6
Bipolar Disorder
Genetic Pedigree
Manic Disorder
Genomics
8
701
1
Paper Details
References
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  • Citations378
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  • References13
  • Citations378
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Estimating missing heritability for disease from genome-wide association studies

American Journal of Human Genetics

Mar 8, 2011

Sang Hong LeePeter M Visscher

PMID: 21376301

DOI: 10.1016/j.ajhg.2011.02.002

Abstract

Genome-wide association studies are designed to discover SNPs that are associated with a complex trait. Employing strict significance thresholds when testing individual SNPs avoids false positives at the expense of increasing false negatives. Recently, we developed a method for quantita...read more

Mentioned in this Paper

Genome-Wide Association Study
In Silico
IIeocolitis
Genome
Dysequilibrium Syndrome
Chromosomes, Human, Pair 6
Bipolar Disorder
Genetic Pedigree
Manic Disorder
Genomics
8
701
1

Similar Papers Found In These Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Mania

Mania is a state of heightened affect, energy, and arousal that usually occurs in the context of bipolar disorder. Find the latest research on mania here.

Related Papers

American Journal of Human Genetics

GCTA: a tool for genome-wide complex trait analysis

American Journal of Human GeneticsDecember 21, 2010
Jian YangPeter M Visscher
Paper Details
References
  • References13
  • Citations378
12
  • References13
  • Citations378
12345...
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