Estimating relatedness between individuals in general populations with a focus on their use in conservation programs

Genetics
Pieter A OliehoekPiter Bijma

Abstract

Relatedness estimators are widely used in genetic studies, but effects of population structure on performance of estimators, criteria to evaluate estimators, and benefits of using such estimators in conservation programs have to date received little attention. In this article we present new estimators, based on the relationship between coancestry and molecular similarity between individuals, and compare them with existing estimators using Monte Carlo simulation of populations, either panmictic or structured. Estimators were evaluated using statistical criteria and a diversity criterion that minimized relatedness. Results show that ranking of estimators depends on the population structure. An existing estimator based on two-gene and four-gene coefficients of identity performs best in panmictic populations, whereas a new estimator based on coancestry performs best in structured populations. The number of marker alleles and loci did not affect ranking of estimators. Statistical criteria were insufficient to evaluate estimators for their use in conservation programs. The regression coefficient of pedigree relatedness on estimated relatedness (beta2) was substantially lower than unity for all estimators, causing overestimation of th...Continue Reading

References

Jul 1, 1964·Journal of Theoretical Biology·W D Hamilton
Dec 1, 1996·Genetics·M WeiW G Hill
Apr 1, 1997·Journal of Animal Science·T H Meuwissen
Aug 3, 1999·Genetics·M Lynch, K Ritland
Nov 13, 2002·Genetics, Selection, Evolution : GSE·Herwin EdingTheo H E Meuwissen
Mar 29, 2003·Genetics·Brook G Milligan
Feb 1, 1949·The Journal of Heredity·L O EMIK, C E TERRILL
Mar 1, 1989·Evolution; International Journal of Organic Evolution·David C Queller, Keith F Goodnight

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Citations

May 13, 2009·Journal of Applied Genetics·E Bomcke, N Gengler
Jul 20, 2011·Genetics Research·Z G VitezicaA Legarra
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·J FernándezA Mäki-Tanila
Dec 15, 2010·Nature Genetics·Jodie N PainterKrina T Zondervan
Jan 24, 2008·Proceedings. Biological Sciences·J M Pemberton
Aug 8, 2009·Genetics, Selection, Evolution : GSE·Pieter A OliehoekArie van der Meijden
Mar 17, 2009·Genetics, Selection, Evolution : GSE·Pieter A Oliehoek, Piter Bijma
Jul 14, 2011·Genetics, Selection, Evolution : GSE·Miguel Angel ToroAndrés Legarra
Nov 2, 2007·Journal of Zhejiang University. Science. B·Ken G DoddsBenoît Auvray
Jul 2, 2008·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Marco C A M BinkElizabeth A Thompson
Aug 4, 2009·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·S Mucha, J J Windig
Mar 1, 2008·Molecular Ecology Resources·Dmitry A Konovalov, Dik Heg
Jul 25, 2008·Reproduction in Domestic Animals = Zuchthygiene·H J BertschingerA van Dyk
Apr 1, 2008·Journal of Evolutionary Biology·R B O'HaraJ S Alho
Feb 1, 2012·Molecular Ecology·Eric Vander WalJosé A Andrés
Nov 9, 2011·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·M A R de CaraB Villanueva
Sep 14, 2010·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·D M GorbachM F Rothschild
Nov 9, 2011·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·K A EngelsmaJ J Windig
Apr 5, 2013·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Andiara Silos Moraes de Castro e SouzaCarolina Isabel Miño
May 15, 2012·Genetic Epidemiology·Nicholas A FurlotteSusana Eyheramendy
May 16, 2012·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·K A EngelsmaJ J Windig
Nov 13, 2015·BMC Bioinformatics·David Edwards
Nov 19, 2014·Nature Reviews. Genetics·Doug Speed, David J Balding

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