PMID: 9438927Jan 24, 1998Paper

Estimating residence times and their associated errors in patient absorbed-dose calculation

Journal of Nuclear Medicine Technology
D D KaplanJ Y Wong

Abstract

An approach for estimating organ residence times (tau) and their errors in patient internal emitter radiation dosage calculations has been determined. Using a modeling algorithm and its associated parameters, chimeric anti-CEA monoclonal antibody (cT84.66) patient organ uptake data and residence times of source organ activity were calculated. Through the covariance matrix of the model's parameters and subsequent Monte Carlo simulations, errors in organ residence time (gamma tau) also were estimated These relative tau errors were found to be model-dependent; increasing as the number of organs being simultaneously modeled in a set of two patients being considered for 90Y-cT84.66 radioimmunotherapy. Use of modeling and Monte Carlo methods provide a general, direct procedure for calculating the degree of accuracy of activity integrals and other mathematical functions of kinetic variables.

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