Estimating Residence Times of Lymphocytes in Ovine Lymph Nodes

Frontiers in Immunology
Margaret M McDaniel, Vitaly V Ganusov

Abstract

The ability of lymphocytes to recirculate between blood and secondary lymphoid tissues such as lymph nodes (LNs) and spleen is well established. Sheep have been used as an experimental system to study lymphocyte recirculation for decades and multiple studies document accumulation and loss of intravenously (i.v.) transferred lymphocytes in efferent lymph of various ovine LNs. Yet, surprisingly little work has been done to accurately quantify the dynamics of lymphocyte exit from the LNs and to estimate the average residence times of lymphocytes in ovine LNs. In this work we developed a series of mathematical models based on fundamental principles of lymphocyte recirculation in the body under non-inflammatory (resting) conditions. Our analysis suggested that in sheep, recirculating lymphocytes spend on average 3 h in the spleen and 20 h in skin or gut-draining LNs with a distribution of residence times in LNs following a skewed gamma (lognormal-like) distribution. Our mathematical models also suggested an explanation for a puzzling observation of the long-term persistence of i.v. transferred lymphocytes in the efferent lymph of the prescapular LN (pLN); the model predicted that this is a natural consequence of long-term persistenc...Continue Reading

References

Apr 1, 1976·The Journal of Experimental Medicine·R N CahillZ Trnka
Apr 1, 1992·European Journal of Immunology·C R MackayW R Hein
Mar 1, 1990·The Journal of Experimental Medicine·C R MackayL Dudler
Jan 1, 1989·Immunology Today·A Duijvestijn, A Hamann
Jan 1, 1988·Advances in Experimental Medicine and Biology·R PabstS T Licence
Jun 1, 1986·Immunological Reviews·M Miyasaka, Z Trnka
Nov 1, 1987·The American Review of Respiratory Disease·R PabstM Peter
Dec 1, 1969·The Journal of Experimental Medicine·C GriscelliR T McCluskey
Jun 1, 1974·Klinische Wochenschrift·F Trepel
Apr 1, 1967·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·J G Hall
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A J YoungL Dudler
Mar 6, 2003·The Journal of Clinical Investigation·Shaun M HonigJonathan S Bromberg
Jan 14, 1964·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J L GOWANS, E J KNIGHT
Jun 1, 1965·The Journal of Experimental Medicine·J G HALL, B MORRIS
Dec 14, 2004·Immunologic Research·Patrick Schaerli, Bernhard Moser
Mar 18, 2005·Annual Review of Immunology·Jason G Cyster
Apr 15, 2005·Molecular Immunology·Lisa M EbertBernhard Moser
Apr 14, 2006·Veterinary Research·Diane Bimczok, Hermann J Rothkötter
Jan 20, 2007·Journal of Leukocyte Biology·Ildiko Van RhijnAd P Koets
Oct 30, 2007·Trends in Immunology·Vitaly V Ganusov, Rob J De Boer
Feb 17, 2010·The Journal of Experimental Medicine·David MasopustRafi Ahmed
Feb 23, 2010·Current Opinion in Immunology·Malcolm K Brenner, Helen E Heslop
Apr 23, 2010·Immunology·Federica M Marelli-BergAlf Hamann
Dec 14, 2011·Annual Review of Immunology·Jason G Cyster, Susan R Schwab
Dec 14, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manouk VrielingAd Koets
Mar 31, 2012·Trends in Immunology·Reinhold FörsterTim Worbs
Apr 21, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marc K Jenkins, James J Moon
Oct 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Judith N MandlRonald N Germain
May 17, 2014·PLoS Computational Biology·Vitaly V Ganusov, Jeremy Auerbach
Aug 8, 2014·PLoS Computational Biology·Johannes TextorJoost B Beltman
Apr 4, 2015·Science·Steven A Rosenberg, Nicholas P Restifo
Mar 5, 2016·Nature Reviews. Neurology·Alexander WinkelmannUwe K Zettl
Apr 1, 2007·Journal of Leukocyte Biology·Ildiko Van RhijnAd P Koets
Mar 3, 2019·Science Immunology·Steven M LewisStephanie C Eisenbarth
Aug 6, 2019·Frontiers in Immunology·Margaret M McDaniel, Vitaly V Ganusov

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Citations

Aug 6, 2019·Frontiers in Immunology·Margaret M McDaniel, Vitaly V Ganusov
Apr 29, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marie Colombe AgahozoCarolien H M van Deurzen
Nov 20, 2020·PLoS Computational Biology·Colin T Barker, Naveen K Vaidya

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