Aug 14, 2014

Estimating strength of polygenic selection with principal components analysis of spatial genetic variation

bioRxiv
Davide Piffer

Abstract

Principal components analysis on allele frequencies for 14 and 50 populations (from 1K Genomes and ALFRED databases) produced a factor accounting for over half of the variance, which indicates selection pressure on intelligence or genotypic IQ. Very high correlations between this factor and phenotypic IQ, educational achievement were observed (r>0.9 and 0.8), also after partialling out GDP and the Human Development Index. Regression analysis was used to estimate a genotypic (predicted) IQ also for populations with missing data for phenotypic IQ. Socio-economic indicators (GDP and Human Development Index) failed to predict residuals, not providing evidence for the effects of environmental factors on intelligence. Another analysis revealed that the relationship between IQ and the genotypic factor was not mediated by race, implying that it exists at a finer resolution, a finding which in turn suggests selective pressures postdating sub-continental population splits. Genotypic height and IQ were inversely correlated but this correlation was mostly mediated by race. In at least two cases (Native Americans vs East Asians and Africans vs Papuans) genetic distance inferred from evolutionarily neutral genetic markers contrasts markedly ...Continue Reading

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Mentioned in this Paper

Biological Markers
American
Mongoloid Population
Genome
Guanosine Diphosphate
Spatial Distribution
Posterior Cerebral Commissure
Intelligence
Genetic Markers
Human Development

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