Estimating structural properties of trabecular bone from gray-level low-resolution images

Medical Engineering & Physics
Zbisław Tabor

Abstract

In this paper the relationship between three-dimensional histomorphometric parameters derived from microCT and MRI images of distal radius trabecular bone samples is studied. microFE analysis of the trabecular samples is performed and Young's modulus for cranio-caudal direction is calculated. Most of the MRI and microCT parameters correlate significantly with, respectively, MRI and microCT estimates of bone volume fraction. For some of the parameters strong correlation between microCT and MRI results is also observed. However, in these cases there simultaneously exists correlation between: microCT parameter and microCT bone volume fraction; microCT and MRI bone volume fraction; MRI bone volume fraction and MRI parameter. It is found that, comparing to bone volume fraction, histomorphometric information derived from binarized MRI images does not improve estimation of the Young's modulus of trabecular bone samples (calculated for "gold standard" microCT data). Thus a novel method of "optimal paths" analysis of gray-level MRI images is introduced. "Optimal paths" parameters improve estimation of the Young's modulus of trabecular bone samples. They also provide surrogate, gray-level image-based measure of trabecular thickness.

References

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Citations

May 26, 2012·TheScientificWorldJournal·Tomasz TopolińskiKrzysztof Nowicki
Nov 10, 2009·Medical Engineering & Physics·Zbisław Tabor
Oct 6, 2009·Medical Engineering & Physics·Zbisław Tabor
Jul 25, 2009·Journal of the Mechanical Behavior of Biomedical Materials·Daniel LinMichael Swain
Dec 19, 2006·Bone·Zbisław Tabor, Eugeniusz Rokita
Aug 22, 2006·Medical Engineering & Physics·Zbisław Tabor, Eugeniusz Rokita

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