Estimating the basic reproductive ratio for the Ebola outbreak in Liberia and Sierra Leone

Infectious Diseases of Poverty
Adnan KhanMudassar Imran

Abstract

Ebola virus disease has reemerged as a major public health crisis in Africa, with isolated cases also observed globally, during the current outbreak. To estimate the basic reproductive ratio R0, which is a measure of the severity of the outbreak, we developed a SEIR (susceptible-exposed-infected-recovered) type deterministic model, and used data from the Centers for Disease Control and Prevention (CDC), for the Ebola outbreak in Liberia and Sierra Leone. Two different data sets are available: one with raw reported data and one with corrected data (as the CDC suspects under-reporting). Using a deterministic ordinary differential equation transmission model for Ebola epidemic, the basic reproductive ratio R0 for Liberia resulted to be 1.757 and 1.9 for corrected and uncorrected case data, respectively. For Sierra Leone, R0 resulted to be 1.492 and 1.362 for corrected and uncorrected case data, respectively. In each of the two cases we considered, the estimate for the basic reproductive ratio was initially greater than unity leading to an epidemic outbreak. We obtained robust estimates for the value of R0 associated with the 2014 Ebola outbreak, and showed that there is close agreement between our estimates of R0. Analysis of our ...Continue Reading

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Citations

Dec 10, 2015·ELife·Jean-Paul ChretienDylan B George
Sep 9, 2015·Scientific Reports·Zhi-Qiang XiaZhen Jin
Apr 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Li-Qun FangWu-Chun Cao
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