Estimating the comparative efficacy of cladribine tablets versus alternative disease modifying treatments in active relapsing-remitting multiple sclerosis: adjusting for patient characteristics using meta-regression and matching-adjusted indirect treatment comparison approaches

Current Medical Research and Opinion
Andrea BerardiSchiffon L Wong

Abstract

To estimate the comparative efficacy of cladribine tablets versus alternative disease modifying therapies (DMTs) - fingolimod, natalizumab, alemtuzumab and ocrelizumab - in adults with active relapsing-remitting multiple sclerosis (RRMS), using meta-regression to provide subpopulation-specific estimates of drug effect. Additionally, to determine the feasibility of conducting a matching-adjusted indirect comparison (MAIC) to validate the meta-regression results. A published systematic literature review (SLR) identified studies evaluating the efficacy of cladribine tablets and alternative DMTs in the management of active RRMS. A series of meta-regression models were run with adjustment for baseline risk, fitted to data from the intention-to-treat cohorts of trials identified in the SLR. A non-parametric MAIC analysis adjusted for differences between studies by reweighting patient-level data from the index trial to match the mean baseline characteristics reported for trials with only aggregate data. The meta-regression analysis showed significant overlap in credible intervals for the hazard ratios of 6 month confirmed disability progression (CDP-6M) and annualized relapse rate (ARR), with no therapy statistically dominating in ter...Continue Reading

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Citations

Jan 18, 2020·Journal of Comparative Effectiveness Research·Elyse SwallowJames Signorovitch
Dec 25, 2019·Advances in Therapy·Petri MankinenElina Järvinen
Aug 25, 2019·Applied Health Economics and Health Policy·Renée Else MichelsMarieke Krol
Apr 13, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Aurora ZanghìEmanuele D'Amico
Apr 27, 2021·Multiple Sclerosis and Related Disorders·Veronica Tsin Fong VooMastura Monif
May 25, 2021·Current Treatment Options in Neurology·Alexandra SimpsonScott D Newsome
Sep 6, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N A AvxentyevD L Klabukova

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