Estimating the consequences of anti-psychotic induced weight gain on health and mortality rate

Psychiatry Research
K R FontaineD B Allison

Abstract

Many anti-psychotic medications produce marked weight gain. In this study, we estimate the expected impact of degrees of antipsychotic-induced weight gain on selected mortality rate and incidence rates of impaired glucose tolerance (IGT) and hypertension (HTN) among US adults. Using raw data from 5209 respondents from the Framingham Heart Study's public use data set and national statistics on population demographics, we estimated the expected effect of weight gain on number of deaths and incident cases of IGT and HTN for a 10-year period commencing in 1999. Results indicated that the estimated deleterious effects of weight gain were greater for people with higher BMIs at baseline, for greater degrees of weight gain, for men than women, and for older than younger persons. Because there is a 'U-shaped' relation between BMI and mortality rate, small to moderate weight gains among people with baseline BMIs less than 23 were predicted to decrease mortality rates, whereas weight gains among people with baseline BMIs above that level were expected to increase mortality rates. However, the relations of IGT and HTN with BMI are monotonically increasing. Thus, the anticipated effect of weight gain on IGT and HTN is deleterious regardless...Continue Reading

References

Feb 1, 1980·American Journal of Public Health·S G Haynes, M Feinleib
Sep 14, 1995·The New England Journal of Medicine·J E MansonF E Speizer
Feb 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·T Stedman, J Welham
Mar 3, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K M FlegalC L Johnson
Apr 21, 1998·Biological Psychiatry·F R FrankenburgF Centorrino
May 2, 1998·The Australian and New Zealand Journal of Psychiatry·J K Sharpe, A P Hills
May 21, 1998·The New England Journal of Medicine·D A RedelmeierG L Booth
Jun 18, 1998·European Journal of Clinical Nutrition·L LissnerL Sjöström
Oct 30, 1998·Journal of Psychiatric Research·M D Jibson, R Tandon
Dec 16, 1998·The British Journal of Psychiatry : the Journal of Mental Science·E C Harris, B Barraclough
Apr 30, 1999·The Journal of Clinical Psychiatry·D B AllisonL J Cheskin
Jul 13, 1999·The Journal of Clinical Psychiatry·K N ChengappaN R Schooler
Sep 25, 1999·Southern Medical Journal·L J CheskinC Contoreggi
Jun 1, 2000·The American Journal of Psychiatry·D C HendersonD C Goff
Aug 19, 2000·BMJ : British Medical Journal·U OsbyP Sparén
Oct 21, 2000·The British Journal of Psychiatry : the Journal of Mental Science·S BrownB Barraclough
Mar 1, 1951·American Journal of Public Health and the Nation's Health·T R DAWBERF E MOORE
Sep 1, 1995·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·D B Allison, F X Pi-Sunyer

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Citations

Dec 26, 2006·Social Psychiatry and Psychiatric Epidemiology·Chiara SameleRobin Murray
Jan 30, 2008·European Journal of Clinical Pharmacology·Silvio Garattini, Vittorio Bertele'
Dec 12, 2012·Current Atherosclerosis Reports·Junzo WatanabeToshiyuki Someya
Jun 19, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Daniel J MüllerJames L Kennedy
Mar 26, 2003·Journal of Psychiatric Research·Ulrich ZimmermannThomas Pollmächer
May 30, 2002·Life Sciences·Martina C M Ryan, Jogin H Thakore
Apr 8, 2003·Thrombosis Research·Walter AgenoAchille Venco
Mar 7, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nicholas M WallingfordMichael A Cowley
Apr 3, 2004·Nature Reviews. Drug Discovery·Bryan L RothWesley K Kroeze
Mar 17, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Igor ElmanScott E Lukas
May 20, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Murray A RaskindDennis D Rasmussen
Jul 20, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Peter J WeidenHarold E Lebovitz
May 14, 2008·The Australian and New Zealand Journal of Psychiatry·Sanil Rege
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Trino BaptistaMaritza Martinez
May 16, 2008·Epidemiologic Reviews·John McGrathJoy Welham
Jul 20, 2002·International Clinical Psychopharmacology·U WernekeT A B Sanders
Jul 14, 2007·International Journal of Clinical Practice·A TschonerC F Ebenbichler
May 31, 2003·BMJ : British Medical Journal·Silvio GarattiniLuca Li Bassi
Jun 22, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·David M GardnerPaul Waraich
Jan 29, 2011·Primary Care Companion to the Journal of Clinical Psychiatry·Kornelia GillhoffWaldemar Greil
Jan 29, 2016·Journal of Autism and Developmental Disorders·Lisa M RuizDeborah A Bilder
Jan 26, 2016·Psychiatry Research·Virginie-Anne ChouinardDost Öngür
Jun 20, 2012·Neuropharmacology·Steven P Vickers, Peter G Clifton
Nov 22, 2011·The Psychiatric Clinics of North America·Robert F Kushner, David B Sarwer
Mar 27, 2009·Schizophrenia Research·Bruce ParsonsCynthia Siu
Jun 24, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kazuhide TanakaShigeto Yamawaki
Aug 15, 2003·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S TardieuO Blin
Oct 9, 2003·Acta Psychiatrica Scandinavica·G FaulknerK Lloyd
Sep 11, 2009·International Journal of Mental Health Nursing·Richard GrayKathryn Hoehn Anderson
Sep 6, 2003·Acta Psychiatrica Scandinavica·U WernekeS Wessely
Oct 5, 2010·International Journal of Mental Health Nursing·Sheila Hardy, Richard Gray
Feb 22, 2011·The Psychiatric Clinics of North America·Rohan Ganguli, Martin Strassnig
Jul 5, 2011·Expert Review of Neurotherapeutics·Maurizio PompiliPaolo Girardi

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