Estimating the contribution of genetic variants to difference in incidence of disease between population groups.

European Journal of Human Genetics : EJHG
Ramal MoonesingheMuin J Khoury

Abstract

Genome-wide association studies have identified multiple genetic susceptibility variants to several complex human diseases. However, risk-genotype frequency at loci showing robust associations might differ substantially among different populations. In this paper, we present methods to assess the contribution of genetic variants to the difference in the incidence of disease between different population groups for different scenarios. We derive expressions for the contribution of a single genetic variant, multiple genetic variants, and the contribution of the joint effect of a genetic variant and an environmental factor to the difference in the incidence of disease. The contribution of genetic variants to the difference in incidence increases with increasing difference in risk-genotype frequency, but declines with increasing difference in incidence between the two populations. The contribution of genetic variants also increases with increasing relative risk and the contribution of joint effect of genetic and environmental factors increases with increasing relative risk of the gene-environmental interaction. The contribution of genetic variants to the difference in incidence between two populations can be expressed as a function o...Continue Reading

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Citations

Dec 19, 2014·International Journal of Environmental Research and Public Health·Ramal MoonesingheAna Penman-Aguilar
Feb 11, 2015·PloS One·Jinping ZhangUNKNOWN China National Diabetes and Metabolic Disorders Study Group
Sep 27, 2019·Scientific Reports·Rodrigo SecolinDavid Comas
Nov 30, 2016·World Journal of Gastroenterology : WJG·Zhao-Shan NiuWen-Hong Wang

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