Estimating the discretization dependent accuracy of perfusion in coupled capillary flow measurements

PloS One
Erik A HansonErlend Hodneland

Abstract

One-compartment models are widely used to quantify hemodynamic parameters such as perfusion, blood volume and mean transit time. These parameters are routinely used for clinical diagnosis and monitoring of disease development and are thus of high relevance. However, it is known that common estimation techniques are discretization dependent and values can be erroneous. In this paper we present a new model that enables systematic quantification of discretization errors. Specifically, we introduce a continuous flow model for tracer propagation within the capillary tissue, used to evaluate state-of-the-art one-compartment models. We demonstrate that one-compartment models are capable of recovering perfusion accurately when applied to only one compartment, i.e. the whole region of interest. However, substantial overestimation of perfusion occurs when applied to fractions of a compartment. We further provide values of the estimated overestimation for various discretization levels, and also show that overestimation can be observed in real-life applications. Common practice of using compartment models for fractions of tissue violates model assumptions and careful interpretation is needed when using the computed values for diagnosis and...Continue Reading

References

Dec 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R M Henkelman
Nov 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L OstergaardB R Rosen
Jun 20, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ona WuA Gregory Sorensen
Feb 8, 2006·Journal of Magnetic Resonance Imaging : JMRI·Renate GrünerTorfinn Taxt
Jun 10, 2011·Physics in Medicine and Biology·Adriënne M MendrikMathias Prokop
Jul 23, 2011·Korean Circulation Journal·Young-Il Cho, Daniel J Cho
Mar 14, 2012·IEEE Transactions on Medical Imaging·Timothé BoutelierMakoto Sasaki
Jan 25, 2013·International Journal for Numerical Methods in Biomedical Engineering·C MichlerN P Smith
Mar 15, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Romain GuibertFranck Plouraboué
Jan 1, 2012·Comprehensive Physiology·Mary I Townsley
May 16, 2013·NMR in Biomedicine·Steven P Sourbron, David L Buckley
Oct 3, 2013·Progress in Nuclear Magnetic Resonance Spectroscopy·Fernando Calamante
Apr 9, 2014·IEEE Transactions on Medical Imaging·Steven Sourbron
Apr 7, 2016·Interventional Neurology·Maxim MokinAdnan H Siddiqui

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Citations

May 29, 2021·Physiological Measurement·Stefan HindelLutz Lüdemann

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