Estimating the potential population impact of stepwise screening strategies for identifying and treating individuals at high risk of Type 2 diabetes: a modelling study.

Diabetic Medicine : a Journal of the British Diabetic Association
Parinya ChamnanS J Griffin

Abstract

Diabetes risk assessment has been proposed as part of the National Health Service Health Checks programme, and HbA(1c) has recently been recommended as a diagnostic test for diabetes at a threshold of 48 mmol/mol (6.5%). We estimated the potential population impact of different stepwise screening strategies to identify individuals at high risk who might be offered preventive interventions. Using data from 5910 participants in the European Prospective Investigation of Cancer (EPIC)-Norfolk cohort with HbA(1c) measurements, we modelled different stepwise screening strategies for identifying and treating individuals at high risk of Type 2 diabetes using different HbA(1c) cut-off points with and without a stage of prestratification. For each strategy, we estimated the number needed to have a diagnostic test, the number needed to treat to prevent one new case of Type 2 diabetes, and the number of new cases that could be prevented in the population over 3 years. Relative risk reductions for estimated effects of intensive lifestyle intervention were derived from the US Diabetes Prevention Program. Compared with inviting all individuals in an average primary care trust for a diagnostic test, a stepwise screening approach using simple r...Continue Reading

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Citations

Dec 20, 2015·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·David EpsteinSimon G Thompson
Jul 15, 2015·Diabetes Technology & Therapeutics·Ziad A MemishMohammed K Ali
Oct 29, 2013·Preventive Medicine·Laura C RosellaDouglas G Manuel
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Aug 22, 2015·Journal of Diabetes Science and Technology·William Corser, Sha Yuan
Nov 30, 2019·The Journal of Clinical Endocrinology and Metabolism·Vanessa KraegeMarie Méan
Jun 28, 2019·International Journal of Impotence Research·Afonso MorgadoCarlos Martins Silva

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