Estimating the proportion of people with chronic hepatitis B virus infection eligible for hepatitis B antiviral treatment worldwide: a systematic review and meta-analysis.

The Lancet. Gastroenterology & Hepatology
Mingjuan TanYvan Hutin

Abstract

In 2016, of the estimated 257 million people living with chronic hepatitis B virus (HBV) infection worldwide, only a small proportion was diagnosed and treated. The insufficiency of information on the proportion of people infected with HBV who are eligible for treatment limits the interpretation of global treatment coverage. We aimed to estimate the proportion of people with chronic HBV infection who were eligible for antiviral treatment worldwide, based on the WHO 2015 guidelines. In this systematic review and meta-analysis, we searched Medline, EMBASE, and the Cochrane databases from Jan 1, 2007, to Jan 31, 2018, for studies describing HBsAg-positive people in the population or health-care facilities. We extracted information from published studies using a standardised form to estimate the frequency of cirrhosis, abnormal alanine aminotransferase (ALT), HBV DNA exceeding 2000 IU/mL or 20 000 IU/mL, presence of HBeAg, and eligibility for treatment as per WHO and other guidelines as reported in the studies. We pooled proportions through meta-analysis with random effects. The study was registered with PROSPERO, CRD42020132345. Of the 13 497 studies, 162 were eligible and included in our analysis. These studies included 145 789 p...Continue Reading

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Citations

Feb 15, 2021·The Lancet. Gastroenterology & Hepatology·Daniel Q Huang, Mindie H Nguyen
Apr 11, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Jessica VanhomwegenYusuke Shimakawa
May 1, 2021·Vaccines·Asgeir JohannessenNega Berhe
Jun 3, 2021·International Journal of Molecular Sciences·Ronghua DingGuangcai Duan
Jun 6, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jiyoon ParkMindie H Nguyen
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Aug 10, 2021·World Journal of Hepatology·Syed Tabish RehmanShahab Abid
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Sep 3, 2021·Journal of Hepatology·Qing YeMindie H Nguyen
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Jul 31, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Paul MartinIra M Jacobson

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