Estimating the Risk of Death from COVID-19 in Adult Cancer Patients.

Clinical Oncology : a Journal of the Royal College of Radiologists
M WilliamsS Rabinowicz

Abstract

During the coronavirus disease 2019 (COVID-19) pandemic, organisations have produced management guidance for cancer patients and the delivery of cytotoxic chemotherapy, but none has offered estimates of risk or the potential impact across populations. We combined data from four countries to produce pooled age-banded case fatality rates, calculated the sex difference in survival and used data from four recent studies to convert case fatality rates into age/sex-stratified infection fatality rates (IFRs). We estimated the additional risk of death in cancer patients and in those receiving chemotherapy. We illustrate the impact of these by considering the impact on a national incident cancer cohort and analyse the risk-benefit in some clinical scenarios. We obtained data based on 412 985 cases and 41 854 deaths. The pooled estimate for IFR was 0.92%. IFRs for patients with cancer ranged from 0 to 29% and were higher in patients receiving chemotherapy (0.01-46%). The risk was significantly higher with age and in men compared with women. 37.5% of patients with a new diagnosis of cancer in 2018 had an IFR ≥5%. Survival benefits from adjuvant chemotherapy ranged from 5 to 10% in some common cancers, compared with the increased risk of d...Continue Reading

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Citations

Jan 11, 2021·World Journal of Surgery·Julia MerchantChris Cunningham
Jun 5, 2021·Clinical Lymphoma, Myeloma & Leukemia·Martin ČerňanTomáš Papajík

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Methods Mentioned

BETA
Biopsy

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