Estimating the risk of HIV transmission from homosexual men receiving treatment to their HIV-uninfected partners.

Sexually Transmitted Infections
Timothy B HallettFrank de Wolf

Abstract

To determine how the risk of HIV transmission from homosexual men receiving antiretroviral treatment is related to patterns of patient monitoring and condom use. A stochastic mathematical simulation model was developed of cohorts of men in the Netherlands who have sex with men (MSM), defining the parameters of the model using observational cohort data. The model incorporates viral load trends during first-line treatment, patient monitoring and different scenarios for the way in which condom use may depend on recent viral load measurements. The model does not include the effect of sexually transmitted infections on HIV transmission. For MSM receiving treatment, the risk of transmitting HIV to their long-term partner is 22% (uncertainty interval: 9-37%) if condoms are never used. With incomplete use (in 30% of sex acts) the risk is reduced slightly, to 17% (7-29%). However, the risk is as low as 3% (0.2-8%) when men receiving treatment use condoms only 6 months beyond their last undetectable viral load measurement. The risk is further reduced when 3 months is the time period beyond which condoms are used. When condom use by HIV-infected men receiving combination treatment with antiretroviral agents is based on their last viral lo...Continue Reading

References

Aug 3, 1999·American Journal of Epidemiology·E VittinghoffS P Buchbinder
Oct 3, 2003·AIDS·Ard I van SighemUNKNOWN ATHENA Cohort Study Group
Aug 9, 2005·The American Journal of Medicine·R Scott BraithwaiteMark S Roberts
Mar 4, 2006·AIDS·Beryl A KoblinSusan Buchbinder
Oct 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Christophe FraserWilliam P Hanage
Jan 15, 2008·The Journal of Infectious Diseases·Thomas J PodsadeckiGeorge J Hanna
Jul 29, 2008·Lancet·Geoffrey P Garnett, Brian Gazzard

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Citations

Feb 2, 2012·AIDS Care·Sean C BeougherColleen C Hoff
Nov 19, 2013·Journal of Gay & Lesbian Social Services·Sean C BeougherColleen C Hoff
Mar 26, 2013·Acta Biotheoretica·J DemongeotC Taramasco
May 29, 2012·The Journal of the Association of Nurses in AIDS Care : JANAC·J Craig PhillipsCarol A Pat Patsdaughter
Nov 16, 2013·Archives of Sexual Behavior·Lynne A DarbesColleen C Hoff
Jan 13, 2015·Enfermedades infecciosas y microbiología clínica·Pompeyo Viciana-FernándezUNKNOWN Grupo de trabajo Bridgap
Oct 14, 2011·Journal of the International AIDS Society·Barry D Adam
May 2, 2013·The Cochrane Database of Systematic Reviews·Andrew AnglemyerNandi Siegfried
Apr 23, 2013·JAAPA : Official Journal of the American Academy of Physician Assistants·Kevin Michael O'Hara
Apr 14, 2018·Prevention Science : the Official Journal of the Society for Prevention Research·Tyrel J StarksJeffrey T Parsons

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