Estimating the synaptic concentration of norepinephrine in dentate gyrus which produces beta-receptor mediated long-lasting potentiation in vivo using microdialysis and intracerebroventricular norepinephrine

Brain Research
Carolyn W HarleyDavid J Nutt

Abstract

Norepinephrine in the hippocampus of urethane anesthetized rats was monitored by microdialysis prior to, and following, an intracerebroventricular injection of 5 micrograms [-]NE in 2 microliters of ACSF. The perforant path evoked potential in dentate gyrus was concurrently monitored by a microelectrode adjacent to the dialysis probe. NE levels 30 x basal values or greater at the recording site were related to long-lasting potentiation of the perforant path-evoked population spike. Increases of 3 x to 6 x basal NE values were not accompanied by any potentiation. NE in the midline ventricles alone did not produce potentiation. These results suggest effective NE concentrations for beta-receptor activation of long-term potentiation would only occur near the NE release site.

Citations

Sep 18, 1997·Neuroscience Research·S HamidJ D Stephenson
Feb 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephanie Moriceau, Regina M Sullivan
Jan 10, 2002·Acta Psychiatrica Scandinavica·I HagemanM B Jørgensen
Dec 16, 1998·The British Journal of Psychiatry : the Journal of Mental Science·M O'Brien, D Nutt
Jan 18, 2019·Learning & Memory·Nathan J Brandwein, Peter V Nguyen
Sep 17, 2015·Learning & Memory·Sabyasachi MaityPeter V Nguyen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.