Estimation of absolute renal uptake with technetium-99m dimercaptosuccinic acid: direct comparison with the radioactivity of nephrectomy specimens

São Paulo Medical Journal = Revista Paulista De Medicina
Mariana da Cunha Lopes de LimaEdwaldo Eduardo Camargo

Abstract

Studies using radionuclides are the most appropriate method for estimating renal function. Dimercaptosuccinic acid chelate labeled with technetium-99m (99mTc-DMSA) is the radiopharmaceutical of choice for high-resolution imaging of the renal cortex and estimation of the functional renal mass. The aim of this study was to evaluate a simplified method for determining the absolute renal uptake (ARU) of 99mTc-DMSA prior to nephrectomy, using the radioactivity counts of nephrectomy specimens as the gold standard. Prospective study at the Division of Nuclear Medicine, Department of Radiology, Universidade Estadual de Campinas. Seventeen patients (12 females; range 22-82 years old; mean age 50.8 years old) underwent nephrectomy for various reasons. Renal scintigraphy was performed three to four hours after intravenous administration of a mean dose of 188.7 MBq (5.1 mCi) of 99mTc-DMSA, which was done six to 24 hours before surgery. The in vivo renal uptake of 99mTc-DMSA was determined using the radioactivity of the syringe before the injection (measured using a dose calibrator) and the images of the syringe and kidneys, obtained from a scintillation camera. After surgery, the reference value for renal uptake of 99mTc-DMSA was determine...Continue Reading

References

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Citations

Apr 2, 2015·European Journal of Medicinal Chemistry·A C O SouzaA L Bocca
Oct 16, 2019·Current Radiopharmaceuticals·Masoud RezaeiAmirhossein Ahmadi

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