Estimation of antiphospholipid antibodies in a prospective longitudinal study of children with migraine

Cephalalgia : an International Journal of Headache
T AvcinD Neubauer

Abstract

The aim of this study was to determine the prevalence and clinical significance of antiphospholipid antibodies (aPL) in children with migraine. The values of anticardiolipin (aCL) and antibeta2 glycoprotein I (antibeta2GPI) antibodies were assayed by an ELISA method in 52 children with migraine and 22 children with tension-type headache. The control group consisted of 61 apparently healthy children at regular preventive visits. Two monoclonal beta2GPI dependent aCL (HCAL and EY2C9) were used as calibrators. Lupus anticoagulant (LA) was determined by a modified dilute Russell viper venom time test. Persistently positive aPL were observed during the follow-up in 16.3% of children with migraine (9.3% for aCL, 7.0% for antibeta2GPI and 0% for LA) and in 16.7% of children with tension-type headache (11.1% for aCL, 5.6% for antibeta2GPI and 0% for LA). The prevalence of aPL did not differ significantly between patient groups and healthy children. The prevalence of aPL does not appear to be increased in an unselected group of children with migraine, however, the possible role of aPL in individual cases of paediatric migraine can not be excluded.

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Citations

Jul 16, 2008·Cephalalgia : an International Journal of Headache·F M K WilliamsA J MacGregor
Jun 16, 2006·Acta Neurologica Scandinavica·E PilarskaA Bakowska
Feb 10, 2017·Headache·Gretchen E Tietjen, Stuart A Collins
May 19, 2011·Journal of Thrombosis and Haemostasis : JTH·C CavestroD Roccatello
Apr 10, 2015·Current Rheumatology Reports·Cassyanne L AguiarBarry L Myones
Feb 24, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Le KangOsbert Jianxin Sun
Sep 28, 2017·Cephalalgia : an International Journal of Headache·Md Asiful IslamKah Keng Wong
Dec 14, 2018·Frontiers in Pediatrics·Chris Wincup, Yiannis Ioannou
Jan 22, 2008·Hematology/oncology Clinics of North America·Rima M Dafer, José Biller

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
serum collection

Software Mentioned

MS Excel

Related Concepts

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.