Estimation of botulinum toxin type A efficacy on spasticity and functional outcome in children with spastic cerebral palsy

Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Hristina ColovićDragana Radovic-Janosevic

Abstract

We evaluated the effects of botulinum toxin type A (BTA) - abobotulinumtoxinA on passive motion resistance (PMR) values of lower limbs affected muscles and on the functional motor status in children with spastic cerebral palsy (CP). In Group I (28 lower limbs with spastic muscles), and in Group II (14 lower limbs with dynamic spastic equinus) BTA was administered. Physical therapy was prescribed for 16 weeks. We estimated PMR using the Modified Ashworth Scale. Achieved functional motor level was evaluated by Gross Motor Function Classification System (GMFCS) and Gross Motor Function Measure (GMFM). Parameters were assessed before treatment and after 3,8,16 weeks and 6 months respectively. In Group I, PMR was significantly lower for hip adductors and knee extensors over 3-16 weeks, and for ankle joint extensors in both groups. There were significant differences for both groups in frequencies of GMFCS values after 16 weeks from BTA application. There was a significant increase in GMFM scores after 8 and 16 weeks from BTA application in both groups of patients. BTA treatment in CP children is followed by reduction in PMR values and improvement in functional motor status.

References

Feb 1, 1984·Developmental Medicine and Child Neurology·I ZivJ Koreska
Feb 7, 2001·The Australian & New Zealand Journal of Obstetrics & Gynaecology·E L Beavis
May 30, 2002·Developmental Medicine and Child Neurology·Martin C O Bax
Jun 25, 2004·Journal of Toxicology. Clinical Toxicology
Dec 20, 2005·Developmental Medicine and Child Neurology·H Kerr Graham
Jun 20, 2006·Developmental Medicine and Child Neurology·Olaf Dammann
Nov 23, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J O Dolly, K R Aoki
Mar 21, 2007·Developmental Medicine and Child Neurology. Supplement·Peter RosenbaumBo Jacobsson
Mar 21, 2007·Developmental Medicine and Child Neurology
Sep 19, 2007·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Lidija DimitrijevićIrena Janković
Jan 26, 2008·BMC Bioinformatics·Jing Li, Yixuan Chen
Feb 26, 2008·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yajie Wang, Baoqin Gao
Mar 6, 2008·Developmental Medicine and Child Neurology·Peter L RosenbaumDianne J Russell
Apr 12, 2008·BMC Musculoskeletal Disorders·Akmer MutluMintaze Kerem Gunel
Aug 1, 2009·Physical Medicine and Rehabilitation Clinics of North America·Diane L DamianoHenry Chambers
Mar 13, 2010·Acta Paediatrica·K TedroffH Forssberg
Jul 7, 2010·Journal of Rehabilitation Medicine·Marjolein M van der KrogtJaap Harlaar
Jul 17, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S C LoveUNKNOWN Cerebral Palsy Institute

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