Estimation of cerebral surface area using vertical sectioning and magnetic resonance imaging: a stereological study

Brain Research
Niyazi AcerM Turgut

Abstract

Stereological techniques using isotropic uniform random and vertical uniform random sections have been used for surface area estimation. However, there are a few studies in which the surface area of the brain is estimated using the vertical section technique in a stereological approach. The objective of the current study was to apply the vertical section technique using cycloid test probes for estimation of cerebral surface area in magnetic resonance imaging (MRI). In this study, cerebral surface areas were estimated in a total of 13 young subjects (6 males, 7 females) who were free of any neurological symptoms and signs. The means (+/-S.D.) of the surface areas were 1619.92+/-140. 97 cm (2), 1625.69+/-147. 58 cm(2) and 1674.69+/-160. 60 cm(2) for 36, 18 and 12 vertical sections, respectively. The mean coefficient of error obtained by applying cycloid test lines that use a 2. 8-cm ratio of area associated with each cycloid was estimated at <7% for the three models. No significant difference was found for each of the 36, 18 and 12 vertical sections (p>0.05). In addition, the three models correlated well with each other. From these results, it is concluded that the vertical section technique is an unbiased, efficient and reliable...Continue Reading

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Citations

Dec 15, 2012·Magnetic Resonance Imaging·Carolyn FurlongNeil Roberts
Jan 10, 2018·Frontiers in Neuroanatomy·Lisa BaslerLutz Slomianka
Jul 9, 2020·The Journal of Comparative Neurology·Lutz Slomianka
Feb 5, 2013·Cold Spring Harbor Protocols·Mark J West

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