Estimation of direct causal effects

Epidemiology
Maya L PetersenMark J van der Laan

Abstract

Many common problems in epidemiologic and clinical research involve estimating the effect of an exposure on an outcome while blocking the exposure's effect on an intermediate variable. Effects of this kind are termed direct effects. Estimation of direct effects is typically the goal of research aimed at understanding mechanistic pathways by which an exposure acts to cause or prevent disease, as well as in many other settings. Although multivariable regression is commonly used to estimate direct effects, this approach requires assumptions beyond those required for the estimation of total causal effects. In addition, when the exposure and intermediate variables interact to cause disease, multivariable regression estimates a particular type of direct effect-the effect of an exposure on an outcome when the intermediate is fixed at a specified level. Using the counterfactual framework, we distinguish this definition of a direct effect (controlled direct effect) from an alternative definition, in which the effect of the exposure on the intermediate is blocked, but the intermediate is otherwise allowed to vary as it would in the absence of exposure (natural direct effect). We illustrate the difference between controlled and natural di...Continue Reading

References

Mar 1, 1992·Epidemiology·J M Robins, S Greenland
Nov 5, 1998·Statistics in Medicine·M M Joffe, G A Colditz
Jan 15, 1999·Epidemiology·S GreenlandJ M Robins
Apr 25, 2000·AIDS Research and Human Retroviruses·B N PhenixA D Badley
Aug 24, 2000·Epidemiology·J M RobinsB Brumback
Mar 27, 2002·International Journal of Epidemiology·Stephen R Cole, Miguel A Hernán
May 6, 2003·Biochemical and Biophysical Research Communications·Karuppiah MuthumaniDavid B Weiner

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Citations

Apr 2, 2010·Journal of Autism and Developmental Disorders·Xin ZhangLihong Qi
Mar 16, 2012·Prevention Science : the Official Journal of the Society for Prevention Research·Judea Pearl
Sep 1, 2011·Multivariate Behavioral Research·Kosuke ImaiElizabeth A Stuart
Dec 15, 2010·American Journal of Epidemiology·Sunni L MumfordTyler J VanderWeele
Mar 6, 2009·International Journal of Epidemiology·Danella M Hafeman, Sharon Schwartz
Sep 11, 2013·International Journal of Epidemiology·Lorenzo RichiardiDaniela Zugna
Oct 30, 2008·Journal of the National Cancer Institute·Sholom WacholderNeil Caporaso
Jun 7, 2011·Epidemiology·Tyler J VanderWeele
Dec 14, 2011·Epidemiology·Tyler J VanderWeeleEnrique F Schisterman
Dec 14, 2011·Epidemiology·Richard F MacLehose, Jay S Kaufman
Jun 14, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sheri D WeiserDavid R Bangsberg
Oct 23, 2010·BMJ : British Medical Journal·Jayati Das-MunshiMartin J Prince
Oct 4, 2008·Epidemiologic Perspectives & Innovations : EP+I·Craig A Mason, Shihfen Tu
Sep 8, 2009·Epidemiologic Perspectives & Innovations : EP+I·Sander Greenland, James M Robins
Jan 9, 2010·Environmental Health Perspectives·Irva Hertz-PicciottoIsaac N Pessah
Aug 18, 2012·Environmental Health Perspectives·Colleen E ReidIra B Tager
Mar 23, 2010·The International Journal of Biostatistics·Judea Pearl
May 11, 2011·The International Journal of Biostatistics·Ilya Shpitser, Tyler J VanderWeele
May 11, 2011·The International Journal of Biostatistics·Judea Pearl
Nov 4, 2011·The International Journal of Biostatistics·Peter B GilbertJulian Wolfson
Aug 24, 2013·International Journal of Environmental Research and Public Health·Kristen LyallCheryl K Walker
Jul 17, 2010·The Journal of Rheumatology·William C StrohsnitterRobert N Hoover
Feb 4, 2014·Epidemiology·Eric J Tchetgen Tchetgen, Tyler J Vanderweele
Nov 23, 2013·American Journal of Epidemiology·Theis LangeLau Caspar Thygesen
Apr 20, 2014·Journal of Clinical Psychopharmacology·Konstantinos MargetisDamianos Sakas
Nov 5, 2013·American Journal of Epidemiology·Arnaud ChioleroJay S Kaufman
Apr 10, 2014·Epidemiology·Maya L Petersen, Mark J van der Laan
Aug 12, 2014·American Journal of Epidemiology·Félice Lê-ScherbanHal Morgenstern
Oct 8, 2013·The Journal of Nutrition, Health & Aging·T J HaightI B Tager
Jul 23, 2014·Epidemiology·W Dana FlandersWilliam McClellan
May 27, 2014·International Journal of Epidemiology·Ashley I NaimiRichard F MacLehose
Oct 24, 2009·American Journal of Epidemiology·Danella M Hafeman
Dec 15, 2010·American Journal of Epidemiology·Emily B Levitan
Jul 12, 2012·American Journal of Epidemiology·Theis LangeMaarten Bekaert
Apr 17, 2008·Epidemiology·Andrea Schmidt-Pokrzywniak, Andreas Stang
Oct 7, 2009·Epidemiology·Stijn Vansteelandt
May 27, 2010·Epidemiology·Danella M Hafeman, Tyler J VanderWeele

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