PMID: 3746639Apr 1, 1986Paper

Estimation of drug absorption rates using a deconvolution method with nonequal sampling times

Journal of Pharmacokinetics and Biopharmaceutics
K IgaT Shimamoto

Abstract

A method affording direct estimation of the drug absorption rate from blood level data using arbitrary time intervals has been derived based on the staircase input principle. In the derivation, the drug was assumed to follow linear kinetics where the plasma concentration of the drug after an impulse input is expressed by a multiexponential function. Drug absorption was assumed to occur at a constant rate during each subsequent sampling interval. The absorption rate profiles obtained by the method using several numerical examples were expressed as a set of rectangular pulses. Divergence in the profiles reflected blood sampling measurement errors rather than errors due to the deconvolution. Smoothing of the rate profiles by calculating the mean of the absorption rates between adjacent time intervals gave realistic results. Absorption rate profiles for theophylline obtained by the method using published data gave information on the initiation and termination of the absorption as well as the extent of absorption from the dosage form.

References

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Citations

Jan 1, 1991·Journal of Clinical Pharmacology·G AronoffJ Massarella
Jan 1, 1992·European Journal of Clinical Pharmacology·G PaintaudJ O Svensson
Feb 5, 2013·Journal of Pharmacokinetics and Pharmacodynamics·Josef A Vogt, Christian Denzer
May 7, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kazuhiro SakoTakashi Sonobe
Mar 1, 1993·British Journal of Clinical Pharmacology·H LennernäsL K Paalzow
Mar 1, 1993·British Journal of Clinical Pharmacology·G PaintaudO Ericsson
Jun 1, 1995·The Journal of Pharmacy and Pharmacology·T FunakiI Kuruma
Feb 14, 2012·Computer Methods and Programs in Biomedicine·J G HattersleyN D Evans
Nov 8, 2005·Drug Metabolism and Pharmacokinetics·Shoichi HaradaMitsuru Hashida
Oct 2, 2001·The Journal of Pharmacy and Pharmacology·Y SuzukiY Ogawa
Feb 1, 2015·International Journal of Pharmaceutics·Adnan H MahmoodMichael S Roberts
Sep 1, 1994·Journal of Pharmaceutical Sciences·B HallénB Norén
Apr 17, 2003·Biopharmaceutics & Drug Disposition·Hiromu KondoJun Watanabe
Apr 4, 2003·Biopharmaceutics & Drug Disposition·Hiromu KondoJun Watanabe
Aug 1, 1990·Journal of Pharmacokinetics and Biopharmaceutics·M O Karlsson, A Lindberg-Freijs
Apr 1, 1989·Journal of Pharmacokinetics and Biopharmaceutics·D Verotta
Apr 1, 1990·Journal of Pharmacokinetics and Biopharmaceutics·M O Karlsson, U Bredberg
Dec 1, 1987·Journal of Pharmacokinetics and Biopharmaceutics·V K Piotrovskii

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