Estimation of endothelin-mediated vasoconstriction in acute pulmonary thromboembolism.

Pulmonary Circulation
John Y C Tsang, Wayne J E Lamm

Abstract

We aimed to investigate the role of endothelin-mediated vasoconstriction following acute pulmonary thromboembolism (APTE). Thirteen anesthetized piglets (~25 kg) were ventilated with 0 PEEP. Cardiac output (Qt) and wedge pressure (Pw) were measured by a Swan Ganz catheter, along with arterial and venous blood gases. APTE was induced by autologous blood clots (~0.8 g/kg, 12-16 pieces) via a jugular venous catheter at time = 0 minutes until the mean pulmonary arterial pressure (Ppa) was about 2.5 times the baseline at 30 minutes. Eight control animals (Group 1) received only normal saline afterward, while the remaining five (Group 2) received at time = 40-minute saline plus Tezosentan, a nonspecific endothelin antagonist. The drug was initially given as an intravenous bolus (10 mg/kg), followed by an infusion (2 mg/min) until the end of the experiment at 2 hours. Hemodynamic data were measured before APTE and then at 30-minute intervals. Pulmonary vascular resistance index (PVRI) was calculated as (Ppa-Pw)/CI, where CI was cardiac index or Qt/W (body weight). Fluorescent microspheres (FMS) were used to mark regional blood flows and ventilation for cluster analysis. PVRI acutely increased within minutes and remained high despite s...Continue Reading

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Citations

Nov 26, 2013·Archivos de cardiología de México·Javier Jiménez-DíazJuan Benezet-Peñaranda
May 22, 2020·European Heart Journal. Acute Cardiovascular Care·Mads Dam LyhneAsger Andersen
Mar 18, 2020·Pulmonary Circulation·Mads Dam LyhneAsger Andersen
Jul 15, 2020·European Heart Journal. Acute Cardiovascular Care·Anders KramerJens Erik Nielsen-Kudsk
Feb 21, 2021·European Heart Journal. Acute Cardiovascular Care·Mads Dam LyhneAsger Andersen
Feb 21, 2021·European Heart Journal. Acute Cardiovascular Care·Anders KramerJens Erik Nielsen-Kudsk
Aug 8, 2019·Respiration; International Review of Thoracic Diseases·Caio J FernandesRogerio de Souza

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